Fine Chemical Technologies

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Vol 10, No 5 (2015)
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5-12 59
New acetamide complexes of neodimium bromides Nd(Ur)6(H2O)2]Br3 (I) и [Nd(AA)4(H2O)4]Br3∙H2O (II) (Ur - carbamide; AA - acetamide) were synthesized. The resulting complexes were characterized by chemical analysis, infrared spectroscopy and X-ray diffraction method. It is shown that the coordination of the ligands (water molecules at inner sphere, carbamide and acetamide) by the neodimium atoms occurs through the oxygen atoms, and the coordination polyhedron is a distorted square antiprism (CN = 8). The bromide ions are not coordinated and are located in the outer sphere. The crystals of I contain complex cations [Nd(Ur)6(H2O)2]3+. The shape of the coordination polyhedron for the neodimium atom in I is the transition between the dodecahedron and a distorted tetragonal antiprisms. The shape of the coordination polyhedron for II is closest to the two-capped
13-18 57
The elemental and chemical composition distribution over the indium arsenide anodic oxide films (AOF) thickness created by anodic oxidation in a galvanostatic mode at two current density values in an electrolyte containing fluoride ions are studied by X-ray photoelectron spectroscopy. The received data indicate that AOF consist of the fluoride-oxygen compounds of In and As (In and As oxyfluorides) and indium oxide (In2O3). Fluorine is accumulated near InAs-AOF boundary. Increasing of the current density from 0.05 to 0.5 mA/cm2 at constant value of both forming voltage and electrolyte composition leads to fluorine concentration near AOF-InAs boundary increasing approximately in 3 times. In turn, the forming voltage increasing at fixed current density also increases the fluorine concentration near InAs-AOF boundary but in less extent: with forming voltage increasing on 5 V more the fluorine content in the bulk AOF increases in ~1.2 and ~1.5 times at current densities of 0.05 and 0.5 mA/cm2, respectively. Thus, it is possible to change fluorine content near AOF--InAs boundary at constant fluorine-containing components concentration in initial electrolyte by varying current density and forming voltage of anodic oxidation.
19-26 462
Our work is focused on a development of physical-chemical backgrounds and methods of controlled synthesis of germanium hydroxide GeO(OH)2, which is a precursor for the synthesis of functional materials based on germanium oxide. The method of controlled synthesis of germanium hydroxide by heterophase interaction ammonia solution with germanium tetraiodide was elaborated. It yields hydroxide with relatively low water content (~ 14 wt. %), which can be easily filtrated. The average germanium dioxide content is as higher as 86 wt.%. Physical-chemical properties of germanium hydroxide and products of thermal decomposition have been investigated by using of chemical and thermal analysis, gravimetric analysis, XRDA, IR-spectroscopy.
27-32 34
The theoretical analysis of influence of technological parameters on process operation and efficiency of continuous vacuum-evaporating crystallization in relation to isolation of a number of substances from their water solutions is carried out. Ranges of change of parameters at which carrying out this process is possible are established. It is shown that solution temperature before its pressure reduction, concentration of solution and pressure in a crystallizer have the strongest impact on process operation. Efficiency of process also depends on temperature depressions of solutions and physical and chemical properties of the dissolved substances


33-38 47
In this work partially and completely N-oxidized N-vinylpyrrolidone-2-methyl-5-vinylpyridine copolymers were synthesized. The influence of рН on the reaction course was studied. For obtaining the copolymer N-oxidized by 100% it is necessary to carry out the reaction in an acetate buffer solution. If obtaining the partially N-oxidized copolymer, a citrate buffer solution should be used, which allows carrying out the reaction at a smaller speed and as a result enables to stop the reaction in the necessary range. The dependence of biological activity on the extent of N-oxidation was studied. An immunostimulating effect of N-vinylpyrrolidone-2-methyl-5-vinylpyridine N-oxide copolymers with various extent of N-oxidation was revealed in vivo with an anthrax vaccine.
39-43 55
In this article a scheme was proposed, and the synthesis of octavalent bolaamphiphile with terminal D-mannose residues was carried out. The technique of the laboratory synthesis of this compound was improved using optimisation of the key step of the compound synthesis and purification of the final compound. All intermediate steps of the final compound synthesis were described in detail. The terminal D-mannose residues will allow binding with mannose-specific lectins, for example, on the surface of E. coli morbidising the gastrointestinal tract. The resulting compound can be used as a potential anti-adhesion agent to prevent the development of infectious diseases.
44-47 47
Extracting time and the multiplicity of extraction of furocoumarins from the fruits of Ammi majus were determined on the basis of experimental data, with the use of method of natural scales. The found conditions enable reducing the technological process time and labor, also reducing the consumption of the extraction agent.
48-53 96
The article presents the results of the comparative determination of the quality of four articainecontaining anesthetics. The studies were conducted using high performance liquid chromatography (to determine the content of the active substance and impurities), nuclear magnetic resonance (for the determination of optical isomers (enantiomers)) and potentiometry (to adjust the pH of the drug solution). It was found that the studied drugs do not differ in the quantitative content of the active substance - articaine - and correspond to the requirements of the regulatory documents. The analysis showed the difference in the qualitative and quantitative content of the impurities. It was found that all the samples contained articaine as an equimolar mixture of R/S enantiomers. The pH of the aqueous solutions of the articaine-containing anesthetics varies from 3.37 to 3.96.
54-59 39
Considered the possibility of determining the content of natural multicomponent oils in repellent means from insects and rodents. For the analysis of finished products on the basis of Lavandin oil and a blend of essential oils containing as a main component citral, the method RP HPLC with UV detection as an alternative to more expensive options with mass-selective detection. Proposed methods of group content evaluation components of the oils with reference to a specific substance (citral), or without it. For the development and validation of the final analysis it is necessary to apply a differentiated approach in the evaluation of formulations of active substances containing multicomponent natural mixture. Perhaps the correct procedure of the analysis is to identify not only the main component (for example, citral), and minor/s components, the definition of which will more accurately indicate the actual content in the media compositions of active ingredients of disinfectants.
60-65 53
Disulfiram is an inhibitor of superoxide dismutase, reduced lipid peroxidation, and can be an effective pharmaceutical substance for the treatment of cataracts. Unfortunately, the use of disulfiram in ophthalmology is limited due to its practically insoluble in water. Hydroxypropyl-β-cyclodextrin is an effective solubilizing agent and has long been used in the pharmaceutical industry. Due to its structure hydroxypropyl-β-cyclodextrin forms inclusion complexes with pharmaceutical substance which soluble in water is limited. In this paper it was investigated a new method of obtaining inclusion complex of hydroxypropyl-β-cyclodextrin with disulfiram. Inclusion complex prepared and isolated in powder form, the formation of inclusion complex and its physicochemical properties was confirmed by X-ray powder diffraction and UVspectrophotometry.


66-76 70
We have studied methods for preparing biodegradable microparticles for regenerative medicine based on chitosan, polylactic acid, collagen and gelatin. The main methods of forming particles become emulsification, coacervation and gelation. These methods can achieve the necessary parameters of the product such as size, porosity and shape by varying process parameters such as temperature, stirring speed and the concentration of solutions. For drying the microparticles vacuum freeze drying was used, which allows to maintain the spherical shape of the particles after drying. The resulting microparticles were examined and photographed using a scanning electron microscope. To determine the cytotoxicity of the microparticles their cell growth and attachment were studied in vitro.
77-84 51
The article presents the results of a study on the behavior of water-insoluble ethoxylated surfactants of different nature on the phase boundary by the method of oscillating drops and by the method of Langmuir-Blodgett films. It was shown that the water-insoluble ethoxylated surfactants form supramolecular structures and stable layers at the water/air interface.
85-88 54
The effect of carbon nanofillers (CNF) on the properties of EPDM is studied by a complex of methods. The elastomer was first modified with a curative group (sulfur, zinc oxide, stearic acid, dibenzothiazolylsulfide and tetramethyltiuramdisulfide), and then with CNF. It was found that both the structure and size of the carbon nanofillers affect the properties of EPDM. The addition of nanofibers (Р11) results in an increase in the molecular mobility and strength of the elastomer. The addition of smaller nanotubes results in a glass-transition temperature raise by 8°C.The composition permittivity decreases among Р11, С22, В22 from 7 to 5.

ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)