Comparison of physico-chemical characteristics of some articaine-containing anesthetics used in stomatology
Abstract
The article presents the results of the comparative determination of the quality of four articainecontaining anesthetics. The studies were conducted using high performance liquid chromatography (to determine the content of the active substance and impurities), nuclear magnetic resonance (for the determination of optical isomers (enantiomers)) and potentiometry (to adjust the pH of the drug solution). It was found that the studied drugs do not differ in the quantitative content of the active substance - articaine - and correspond to the requirements of the regulatory documents. The analysis showed the difference in the qualitative and quantitative content of the impurities. It was found that all the samples contained articaine as an equimolar mixture of R/S enantiomers. The pH of the aqueous solutions of the articaine-containing anesthetics varies from 3.37 to 3.96.
About the Authors
A. I. Marakhova
Peoples' Friendship University of Russia, Moscow, 117198
Russian Federation
Institute of Biochemical Technology and Nanotechnology
Russian Federation
Institute of Biochemical Technology and Nanotechnology
M. A. Zhuravleva
Peoples' Friendship University of Russia, Moscow, 117198
Russian Federation
Institute of Biochemical Technology and Nanotechnology
Russian Federation
Institute of Biochemical Technology and Nanotechnology
S. N. Panov
Peoples' Friendship University of Russia, Moscow, 117198
Russian Federation
Institute of Biochemical Technology and Nanotechnology
Russian Federation
Institute of Biochemical Technology and Nanotechnology
Ya. M. Stanishevskiy
Peoples' Friendship University of Russia, Moscow, 117198
Russian Federation
Institute of Biochemical Technology and Nanotechnology
Russian Federation
Institute of Biochemical Technology and Nanotechnology
References
1. Becker D.E., Reed K.L. // Anesth. Prog. 2006. V. 53. P. 98-109.
2. Vree T.B., Gielen M.J. // Best Pract. Res. Clin. Anaesthesiol. 2005. V. 19. P. 293-308.
3. Yapp K.E., Hopcraft M.S., Parashos P. // Br. Dent. J. 2011. V. 210. P. 323-329.
4. Столяренко П.Ю. // Стоматолог-практик. 2010. № 5. С. 46-48.
5. Василенко И.А., Лебедева М.В., Листров В.А. // Разработка и регистрация лекарственных средств. 2015. Т. 1. № 10. С. 92-106.
6. Steinkopf S., Hanekam L., Schaathun M., Budnjo A., Haug B.E., Nerdal W. // Eur. J. Pharm. Sci. 2012. Vol. 47. № 2. Р. 394-401.
7. Столяренко П.Ю. // Стоматолог-практик. 2013. № 3. C. 40-48.
8. Columb M., Ramsaran R. // Anesthesia and Intensive Care Medicine. 2010. V. 11. № 3. Р. 113-117.
9. Malamed S.F., Falkel M. // SAAD Dig. 2013. V. 29. Р. 9-17.
10. Cepeda M.S., Tzortzopoulou A. // Cochrane Database of Systematic Reviews. 2010. V. 12. CD006581.
For citation:
Marakhova A.I., Zhuravleva M.A., Panov S.N., Stanishevskiy Y.M. Comparison of physico-chemical characteristics of some articaine-containing anesthetics used in stomatology. Fine Chemical Technologies. 2015;10(5):48-53. (In Russ.)
Views: 116
Email this article 