Fine Chemical Technologies

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Vol 9, No 3 (2014)
View or download the full issue PDF (Russian)


3-10 312
The present article is devoted to the synthesis and investigation of biological and physico-chemical properties of the bacteriopurpurinimide derivative that was used as a photosensitizer. These substances have an ability to accumulate selectively in the malignant tumours. Also this class of photosensitizers is of particular interest because of their strong light absorbtion spectrum in red and NIR-region in the “window of tissue transparency”. This property affords to treat deep-seated tumours at the depth of 2 cm. In this study it was implemented the method of photodynamic therapy of cancer. The photosensitizer for this study was prepared as the nanostructured water-soluble micellar dispersion of O-propyloxime-N-propoxybacteriopurpurinimide methyl ester. The photodynamic therapy using this substance provided the highly effective photoinduced antitumour in vitro and in vivo activity, 100% regression of the tumour and 90% cure of animals.
11-20 302
Biopharmaceutical technologies using phospholipids for the development of a new generation of pharmaceutical formulations are considered. Industrial methods for isolating phosphatidylcholine from egg yolk and cardiolipin from the heart muscle were implemented at the Biolek company (Kharkov). The industrial production of a number of phospholipid fractions has been mastered too. The latest data concerning the application of nanocontainers for loading classic drugs during the design of modern effective drug formulations are reported. These formulations are used to improve the results of treatment, to provide the targeted drug delivery into pathological foci, to prolong the action time, and to increase the drug solubility. Among the aforementioned containers, special emphasis should be given to liposomes, nanosomal polymeric formulations based on polybutylcyanoacrylates or on polylactides, and spherical amorphous nanoparticles formed from birch bark triterpenoids. The modern state of researches performing by scientific team headed by academician V.I. Shvets is also presented.


21-27 244
A new method based on thermodynamic similarity and experimental data for the isobaric heat capacity of hydrocarbons and mixtures thereof on the saturated liquid line is offered to calculate the adjusted heat capacity for hydrocarbons and mixtures thereof with due regard to the reduced temperature. Formulas have been developed to estimate the reduced heat capacity for the reduced temperature values within the range 0.37< τ <0.92 with an error less than 2.6% for the hydrocarbons and the entire temperature range with an error less than 2.7% for the of mixtures thereof.
28-30 224
On example of A⇔B reaction the influence of hydrodynamic condition in the reactor on recycle flow rate need for determined conversion value is investigated. The continuous stirred tank and plug flow reactors considered.
31-35 246
Some variants of separation of binary eutectic mixtures by combining the processes of fractional crystallization and continuous distillation with using heat pumps are considered. Influence of technological parameters on the yield and energy efficiency of the process in relation to the separation of a binary mixture of benzene and naphthalene is analyzed. It is shown that use of compression heat pumps can significantly reduce energy costs for the separation process.
36-44 258
In this paper algorithm of determination of vapour-liquid equilibria diagram structure for five-component system with and without five-component azeotrope was described. This algorithm allows determining existence, sign of Poincare index and type of five-component azeotrope using principle of azeptropy. One model and one real (acetone–methanol–methyl acetate–ethyl acetate–water) system was analyzed with this algorithm.
45-50 273
In the paper we present the method of calculating the particle size distribution of the initial granules overgranulated by the “fattening” technology. We have developed a number of different ways for solving the problem for the continuous and periodic (transition) process. Knowing the particle size distribution is very important for calculating and planning the production of granulated products, such as fertilizers and many others. Fattening is a process of overgranulating the initial pellet by the powder (with or without binding) by rolling in different devices, including plate granulators. The calculation results obtained with the use of the models are represented as a series of graphic dependencies. A comparison of the proposed calculation methods with those previously known is also given. A block diagram of the implementation of the algorithm is also presented in the paper.


51-56 251
The article is devoted to peculiarities of liquid phase hydrogen peroxide decomposition over transition metal (Ag, Cu, Rh, Pd, N or Co) oxides anchored on mesoporous carbon support. The values of activation energy (Ea) and frequency factor (k0) of the catalytic reaction have been determined with kinetic data at 25–70°C. The reaction rate has been established to depend on the strength of the bond between the transition metal anchored and reactive oxygen species adsorbed. The contribution of free radical mechanism has been estimated with inhibitors of free hydroxy (HO∙) and super-oxide (O2 - ) radicals, e.g., dimethylsulfoxide and potassium chloride, respectively. The mechanism of the liquid phase hydrogen peroxide decomposition over the anchored transition metal oxides has been suggested to involve the formation of surface oxygen-containing transition metal complexes, their decomposition being the limiting step of the reaction.
57-63 258
The kinetic regularities of the conjugated process of the oxidation of carbon monoxide and the hydrocarboxylation of cyclohexene to cyclohexanecarboxylic acid have been studied. The copper(II) bromide addition allowed to stabilize the system and to increase selectivity due to the suppression of side reactions of the cyclohexene conversion and tetrahydrofuran. To achieve the acceptable rate and the selectivity of the transformation to cyclohexanecarboxylic acid it is advisable to use the palladium bromide concentration of 0.05 mol/L. To study the kinetic regularities the lower concentration of palladium bromide of 0.005 mol/L is required to ensure the system stability and the good reproducibility of results. The state of bromide complexes of palladium and copper under the conditions of conjugated catalytic synthesis of cyclohexanecarboxylic acid by the hydrocarboxylation of cyclohexene was studied by electron and infrared spectroscopy. It was found that during the conjugated process, copper exists in the form of copper(I) compounds, and palladium is present in the form of palladium(II) carbonyl complex. Hypotheses about the mechanism of this process were suggested. 24 two-route mechanisms of the carbon dioxide and the cyclohexanecarboxylic acid synthesis were obtained. Each of the 24 hypotheses spawned from one to three hypothetical mechanisms differing in the reversibility of the stages, the amount and the composition of intermediates accounted for in the material balance for the catalyst.


64-70 242
The influence of the aging process on the properties of asphalt binders modified with active powder of discretely devulcanized rubber (APDDR) obtained in rotor dispersers by using the technique of high-temperature shearinduced grinding (HTSG), and other types of modifier. Comprehensive study of asphalt binders according to American Standard Super Pave showed that the use of APDDR can significantly improve not only the level of performance characteristics of asphalt concrete pavement, but the aging resistance of the material during manufacture asphalt mix that is caused as a dry way of introducing this type of modifier and its complex physicochemical properties. Conducted on Dynamic Shear Rheometer test bitumen modified crumb rubber by HTSG showed applicability APDDR particles as an effective modifier asphalt binders and asphalt coatings, designed to work in different climatic zones with the highest loads.
71-73 279
It has been shown that stearic acid has specific effect on the formation of surface properties of butadiene-styrene rubber produced by polymerization in solution, and of rubbers based on it. When stearic acid content is up to 1 wt. parts per 100 wt. parts of rubber, surface tension of samples is reduced, and at higher content the surface tension is increased. These features can be useful in predicting the technological behavior of rubber compositions during their processing.
74-78 237
For polymer Nafion films production containing Pt nanocomposites it was used the influence of gamma radiation 60Co. The platinum nanoparticles were synthesized by the method of radiation-chemical reduction of ions in reverse micelle solutions for subsequent Nafion films modification. It was demonstrated the effect of synthesis conditions, the degree of solubilization and nanoparticle sizes on the catalytic activity of Pt/Nafion nanocomposites. It was shown that the catalytic activity of metal-polymer nanocomposites increase with platinum nanoparticle size decreasing. Functional characteristics of nanocomposites were investigated by cyclic voltammetry and scanning electron microscopy methods. Created nano-catalysts showed high catalytic activity in the oxygen reduction and hydrogen oxidation reactions.
79-85 256
Foaming process of rigid PVC compositions with azodikarbonamid in the presence of different modifying and processing additives was studied. Additives which increase or decrease foaming coefficient of rigid PVC were identified and the reasons of observable phenomenon were examined.
86-91 201
It was investigated influence on the character of the flow of polyethylene melts having rheological additives of different nature. It is proposed method of comprehensive evaluation of the effectiveness of the rheological additives on the flow of melts of polymeric materials in processing conditions.


92-96 245
We provide a formal description of “ехtrасtum rubiae tinctоrum siccum” production by means of functional modeling. The result of such description is a functional-technological mode that is a graphical representation of technological, decision making and quality test processes. The model is provided by IDEF0 functional modeling notation. We describe inputs, outputs, mechanisms and controls for all the processes focusing on the modeling of feedbacks that describe reagent recycling. The model should assist in system analysis of the herbal medicinal products manufacturing. It is the first step of the informational support of the manufacturing process.
98-104 256
We discover and formalize the relations between set properties of the material and its synthesis conditions. We provide a formal description of carbon nanotubes synthesis control by means of functional modeling. The result is the hierarchical structure visual description that is the set of related diagrams. The diagrams describe the technological and control processes of carbon nanotubes synthesis and its relations including feedbacks.
105-111 220
The theory of heat stress for viscoelastic bodies based on linear rheological models of Maxwell and Kelvin for infinite domain bounded from inside by surfaces of either flat or cylindrical, or spherical shape together was examined. The influence of the geometrical factor and features of viscoelastic substances were found.

ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)