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Polyelectrolyte microcapsules modified with nanoscale titanium dioxide for targeted drug delivery

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Polyelectrolyte microcapsules composed of CaCO3-core and shell polydiallyldimethylammonium polistirolsufonatpolystyrenesulfonate, were obtained by Layer-by-Layer-method. They were modified with nanoscale titanium dioxide with rutile structure and commercial Degussa P25 and Hombikat UV-100. Besides it has been shown that the sample Hombikat UV-100 is better included in the capsule shell because of a largerspecific surface area and the presence of hydrated component in composition of sample. Resistance to UVradiation was tested on the capsules modified with Degussa P25. It has been established that the modification takes place only in the case of "thick" shells with the number of bilayers being x=8. In the case of shells with x=4 there is a destruction of polyelectrolyte capsules during modification. It has been found that the degree of modification of capsules by nanosizedtitanium dioxide depends on the shell thickness (value x) as well as on the surface of nanoscale titanium dioxide samples

About the Authors

P. А. Demina
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation

Е. V. Degtyareva
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation

G. M. Kuz’micheva
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation

T. V. Bukreeva
A.V. Shubnikov Institute of Crystallography RAS, Moscow, 119333
Russian Federation


1. Sukhorukov G.B., Donath E., Lichtenfeld H., Knippel H., Knippel M., Budde A., Möhwald H. Layer-by-layer self assembly of polyelectrolyteson colloidal Particles // Colloids Surf. A. 1998. V. 137. P. 253-266.

2. Donath E., Sukhorukov G.B., Caruso F., Davis S., Möhwald H. Novel hollow polymer shells by colloid-templated assembly of polyelectrolytes // Angew. Chem. 1998. V. 37. № 16. P. 2202-2205.

3. Sukhorukov G.B., Donath E., Davis S.A., Lichtenfeld H., Caruso F., Popov V.I., Möhwald H. Stepwise polyelectrolyte assembly on particle surfaces: A Novel Approach to Colloid Design // Polym. Adv. Technol. 1998. V. 9. P. 1-9.

4. Sukhorukov G.B., Shchukin D.G., Dong W. Möhwald H., Lulevich V.V.,Vinogradova O. Comparative analysisof hollowand filled polyelectrolyte microcapsules templatedon melamine formaldehyde and carbonate cores // Macromol. Chem. Phys. 2004. V. 205. P. 530-535.

5. Dejugnat С., Sukhorukov G.B. pH-Responsive properties of hollow polyelectrolyte microcapsules templated on various cores // Langmuir. 2004. V. 20. P. 7265-7269.

6. Shchukin D.G., Sukhorukov G.B. Selective YF3 Nanoparticle Formation in Polyelectrolyte Capsules as microcontainers for yttrium recovery from aqueous solutions // Langmuir. 2003. V. 19. P. 4427-4431.

7. Antipov A., Shchukin D., Fedutik Yu., Zanaveskina I., Klechkovskaya V., Sukhorukov G., Möhwald H. Urease-Catalyzed Carbonate Precipitationinside the Restricted Volume of Polyelectrolyte Capsules // Macromol. Chem. Phys. 2003. V. 24. P. 274-277.

8. Shchukin D.G., Dong W., Sukhorukov G.B. Spatially confined tungstateion polymerization in microcapsules // Macromol. Chem. Phys. 2003. V. 24 (7). P. 462-466.

9. Букреева Т.В., Парахонский Б.В., Скиртач А.Г., Суша А.С., Сухоруков Г.Б. Получение полиэлектролитных микрокапсул с наночастицамисеребра и золота в оболочке и дистанционное разрушение таких капсул воздействием лазерного излучения // Кристаллография. 2006.T. 51. № 5.C. 920-926.

10. Букреева Т.В., Орлова О.А., Сульянов С.Н., Григорьев Ю.В., Дороватовский П.В. Новый способ модификации оболочек полиэлектролитных капсул наночастицами магнетика // Кристаллография. 2011. Т. 56. № 5.C. 940-943.

11. Shirtach A.G., Antipov A.A., Shchukin D.G., Sukhorukov G.B. Remote activation of capsules containing Agnanoparticles and IR dye by laser light // Langmuir. 2004. V. 20. P. 6988-6992.

12. Min Song, Renyun Zhang, Yongyuan Dai, Feng Gao, Huimei Chi, Gang Lv, Baoan Chen, Xuemei Wang. The in vitro inhibition of multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition // Biomaterials. 2006. V. 27. P. 4230-4238.

13. Savinkina E.V. Kuzmicheva G.M., Obolenskaya L.N. Efficient synthesis and properties of η-titania//Proc. of the 2nd Eur. Conf. of Chem. Engineering. Puerto De La Cruz, Spain. 2011.P. 93-96.

14. Volodkin D.V., Petrov A.I., Prevot M., Sukhorukov G.B. Matrix polyelectrolyte microcapsules: new system for macromolecule encapsulation // Langmuir. 2004. V. 20. P. 3398-3406.

15. Volodkin D.V., Larionova N.I., Sukhorukov G.B. Protein encapsulation via porous CaCO3microparticlestemplating// Biomacromolecules.2004. V. 5. № 5. P. 1962-1972.

16. Жилкина А.В., Гордиенко А.А., Прокудина Н.А., Трусов Л.И., Кузьмичева Г.М., Дулина Н.А., Савинкина Е.В. Определение размера частиц высокодисперсных материалов с помощью низкотемпературной адсорбции азота // Журн. физ. химии. 2013. T. 87. № 4.C. 685-691.

17. Demina P.A., Kuz’michev A.N., Tsybinsky A.M., Obolenskaya L.N., Kuz’micheva G.M., Savinkina E.V. Synthesis, characterization and adsorption behavior of Mo (VI) andW (VI) ionson titanium dioxide nanoparticles containing anatasemodification // Applied Nanoscience. 2013. ISSN 2190-5509. Appl Nanosci DOI 10.1007/s13204-013-0279-9.

18. Gorin D.A., Portnov S.A., Inozemtseva O.A., Luklinska Z., Yashchenok A.M.,Pavlov A.M., Skirtach A.G, Möhwald H., Sukhorukov G.B. Magnetic/gold nanoparticle functionalized biocompatible microcapsules withs ensitivity to laser irradiation // Phys. Chem. Chem. Phys. 2008. V. 10. P. 6899-6905.

19. Shchukin D.G., Sukhorukov G.B., Möhwald H. Smart Inorganic/Organic NanocompositeHollow Microcapsules // Angew. Chem. Int. Ed. 2003. V. 42. P. 4471-4475.

20. Nakamura M., Katagiri K., Koumoto K. Preparation of hybrid hollow capsules formed with Fe3O4 and polyelectrolytes via the layer-by-layer assembly and the aqueous solution process // J. Colloid Interface Sci. 2010. V. 341. P. 64-68.

For citation:

Demina P.А., Degtyareva Е.V., Kuz’micheva G.M., Bukreeva T.V. Polyelectrolyte microcapsules modified with nanoscale titanium dioxide for targeted drug delivery. Fine Chemical Technologies. 2014;9(4):73-79. (In Russ.)

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