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COMPOSITIONS BASED ON AQUEOUS SOLUTIONS OF CHITOSAN AND GLUTAR ALDEHYDE FOR EMBOLIZATION OF BLOOD VESSELS

https://doi.org/10.32362/2410-6593-2019-14-1-25-31

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Abstract

The article investigates the aqueous solutions of food chitosan and glutaraldehyde to determine the feasibility of their use as components of an embolizing composition. It was shown on the basis of experimental flow curves, viscosity and velocity curves that test solutions have low viscosity and exhibit Newtonian flow behavior. The activation energy of viscous flow of the fluids was estimated in the temperature range of 25-37 °C within the Arrhenius - Frenkel - Eyring equation. It varies within a narrow range: 17-24 kJ/mol. When mixing the aqueous solutions of food chitosan and glutaraldehyde, chemical interaction of the solutes occurs. It is accompanied by an increase in viscosity and formation of a covalently crosslinked gel. Using a simple exponential equation the effective rate constant of the chemical process was calculated. It varies in a wide range: 1.9-82.7∙103 1/s. These values can be used when selecting an optimal region of food chitosan-glutaraldehyde ratios and concentrations of their aqueous solutions to generate embolizing agents. The conditions at which gel formation takes place over forty seconds were determined. Differential scanning calorimetry indicated a negligible thermal effect of food chitosan reaction with glutaraldehyde in the aqueous medium, which ensures no thermal burn during the formation of an embolus in the blood vessel in situ. As a result of the work elastic solid gels suitable for use as embolizing agents were obtained.

About the Authors

P. E. Ignatieva
MIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Student of the Chair of Biotechnology and Industrial Pharmacy, M.V. Lomonosov Institute of Fine Chemical Technologies,

86, Vernadskogo pr., Moscow, 119571, Russia



E. S. Zhavoronok
MIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Ph.D. (Chemistry), Associate Professor of the Chair of Biotechnology and Industrial Pharmacy, M.V. Lomonosov Institute of Fine Chemical Technologies

86, Vernadskogo pr., Moscow, 119571, Russia



O. A. Legonkova
A.V. Vishnevsky National Medical Research Center of Surgery
Russian Federation

Head of the Department of Dressings, Suture and Polymer Materials in Surgery, A.V. Vishnevskiy

27, Bolshaya Serpukhovskaya st., Moscow, 117997, Russia



S. A. Kedik
MIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

D.Sc. (Engineering), Professor, Head of the Chair of Biotechnology and Industrial Pharmacy, M.V. Lomonosov Institute of Fine Chemical Technologies,

86, Vernadskogo pr., Moscow, 119571, Russia



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Supplementary files

1. The dependence of viscosity on embolus formation time for different ratios of food chitosan and glutaraldehyde (weight part): 3:1 (1), 1:1 (2), 0.24:1, 1:3 (4).
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Ignatieva P.E., Zhavoronok E.S., Legonkova O.A., Kedik S.A. COMPOSITIONS BASED ON AQUEOUS SOLUTIONS OF CHITOSAN AND GLUTAR ALDEHYDE FOR EMBOLIZATION OF BLOOD VESSELS. Fine Chemical Technologies. 2019;14(1):25-31. (In Russ.) https://doi.org/10.32362/2410-6593-2019-14-1-25-31

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)