Fine Chemical Technologies

Advanced search

Therapeutic role of polyunsaturated fatty acids and of their derivatives in pathophysiological processes

Full Text:


This review presents literature data on studies of the therapeutic role of natural polyunsaturated fatty acids and their derivatives in the processes of inflammation, cancer, and immune response.

About the Authors

N. V. Groza
МИТХТ им. М.В. Ломоносова
Russian Federation

A. B. Golovanov
МИТХТ им. М.В. Ломоносова
Russian Federation

E. A. Nalivayko
МИТХТ им. М.В. Ломоносова
Russian Federation

G. I. Myagkova
МИТХТ им. М.В. Ломоносова
Russian Federation


1. Calder P.C. The relationship between the fatty acid composition of immune cells and their function // Prostaglandins Leukotrienes Essent. Fatty Acids. 2008. V. 79. P. 101–108.

2. Cleissman H., John Inge Johnsen J.I., Kogner P. Omega-3 fatty acids in cancer, the protectors of good and the killers of evil? // Exp. Cell Res. 2010. V. 316. P. 1365–1373.

3. Nagatsu M., Watanabe K., Ikemoto N., Murakami N. Synthesis and structure – antitumor-promoting activity relationship of monogalactosyl diacylglycerols // Bioorg. Med. Chem. Lett. 1994. V. 4. P. 1619–1622.

4. Morimoto T., Nagatsu A., Murakami N. Antitumor-promoting glyceroglycolipids from the green alga, Chlorella vulgaris // Phytochem. 1995. V. 5. P. 1433–1437.

5. Jiang W.G., Bryce R.P., Horrobin D.F. Essential fatty acids: Molecular and cellular basis of their anti-cancer action and clinical implication // Crit. Rev. Oncology/Hematology. 1998. V. 27. P. 179–209.

6. Begin M.E., Das U.N., Ells, G. Cytotoxic effects of essential fatty acids (EFA) in mixed cultures of normal and malignant human-cells // Prog. Lipid. Res. 1986. V. 25. P. 573–576.

7. Gardiner N.S, Duncan J.R. Possible involvement of D5-6-desaturase in control of melanoma growth by g-linolenic acid // Prostaglandins Leukotrienes Essent. Fatty Acids. 1991. V. 42. P. 149–153.

8. Dhar, P., Ghosh, S., Bhattacharyya D.K. Dietary effects of conjugated octadecatrienoic fatty acid (9cis, 11trans, 13trans) levels on blood lipids and nonenzymatic in vitro lipid peroxidation in rats // Lipids. 1999. V. 34. P. 109–114.

9. Suzuki R., Noguchi R., Ota T., Abe M. Cytotoxic effect of conjugated trienoic fatty acids on mouse tumor and human monocytic leukemia cells // Lipids. 2001. V. 36. P. 477–482.

10. Igarashi M., Miyazawa T. Newly recognized effect of conjugated trienoic fatty acids on cultured human tumor cells // Cancer Lett. 2000. V. 148. P. 173–179.

11. Adlof R.O., Duval S., Emken E.A. Biosynthesis of conjugated linoleic acid in humans // Lipids. 2000. V. 35. P. 131–135.

12. Heys S.D., Murray A.W., Noble B.S. [et al.] Differential responses of human tumor-cells to polyunsaturated fatty acids stimulation of proliferation of a colon-tumor cell-line by docosahexaenoic acid // Oncol. 1995. V. 7. P. 927–933.

13. Sebedio J.L., Juaneda P., Dobson G., Ramilison I., Martin J.C., Chardigny J.M., Christie W.W. Metabolites of conjugated isomers of linoleic acid (CLA) in the rat // Biochim. Biophys. Acta. 1997. V. 1345. P. 5–10.

14. Coakley M., Ross R.P., Nordgren M., Fitzgerald G. Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species // J. Apl. Microbiol. 2003. V. 94. P. 138–145.

15. Horrobin D.F. Nutritional and medical importance of g‑linolenic acid // Prog. Lipid Res. 1992. V. 31. P. 94–163.

16. Falconer J.S., Ross J.A, Fearon K.H. [et al.] Effect of eicosapentaenoic acid and other fatty acids on the growth in-vitro of human pancreatic-cancer cell-lines // Cancer. 1995. V. 69. P. 826–832.

17. Kitano M., Mori S., Chen T.X. [et al.] Lack of promoting effects of a-linolenic, linoleic or palmitic acid on urinary-bladder carcinogenesis in rats // Cancer. 1995. V. 86. P. 530–534.

18. Slavotinek A., Memillan T.J., Steel C.M. Measurement of radiation survival using the MTT assay // Cancer. 1994. V. 30. P. 1376–1382.

19. Horrobin D.F. Essential fatty acids, lipid peroxidation, and cancer / w-6 Essential fatty acids. – New York: Wisley-Liss, 1990. P. 351–378.

20. Sagar R.P., Das U.N. Cytotoxic action of cis-unsaturated fatty acids on human cervical-carcinoma (HeLa) cells in-vitro // Prostaglandins Leukotrienes Essent. Fatty Acids. 1995. V. 53. P. 287–299.

21. Begin M.E., Ells G., Das U.N., Horrobin D.F. Differential killing of human carcinoma cells suplemented with n-3 and n-6 polyunsaturated fatty acids // Cancer. 1986. V. 77. P. 1053–1062.

22. Pandalai P.K., Pilat M.J., Yamazaki K. [et al.] The effects of w-3 and w-6 fatty-acids on in vitro prostate-cancer growth // Anticancer Res. 1996. V. 16. P. 815–820.

23. Fukui H., Sato T., Sunamoto J. Physicochemical perturbation of α-linolenic acid-related to cell-proliferation //Bull. Chem. Soc. 1994. V. 67. P. 213–218.

24. Hrelia S., Jimenez J.L., Bordoni A. [et al.] Essential fatty acid metabolism in cultured rat cardiomyo-cytes in response to either n-6 or n-3 fatty acid supplementation // Biochem. Biophys. Res. Commun. 1995. V. 216. P. 9–11.

25. Pritchard G.A., Jones D.L., Mansel R.E. Lipids in breast carcinogenesis // Surg. 1989. V. 76. P. 1069–1073.

26. Jiang W.G., Hiscox S., Hallett M.B. [et al.] Inhibition of membrane ruffling and ezrin translocation by g-linolenic acid // Oncol. 1996. V. 9. P. 279–284.

27. Puntis M.C., Jiang W.G. New approaches to cancer treatment: Unsaturated lipids and photodynamic therapy. – New York: Churchill-Livinstone, 1994. P. 40–67.

28. Vartak S., Robbins M.E., Spector A.A. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill // Lipids. 1997. V. 32. P. 283–292.

29. Dutoit P.J., Vanaswegen C.H., Duplessis D.J. The effect of essential fatty acids on growth and urokinase-type plasminogen-activator production in human prostate DU-145 cells // Prostaglandins Leukotrienes Essent. Fatty Acids. 1996. V. 55. P. 173–177.

30. de Bravo M., Schinella G., Tournier H. [et al.] Effects of dietary g- and a‑linolenic acid on a human lung carcinoma growth in nude mice //Med. Science Res. 1994. V. 22. P. 667–668.

31. Devi M.A., Das N.P. Antiproliferative effect of polyunsaturated fatty-acids and interleukin-2 on normal and abnormal human lymphocytes // Experimentia. 1994. V. 50. P. 489–492.

32. Tisdale M.J. Inhibition of lipolysis and muscle protein-degradation by EPA in cancer cachexia // Nutr. 1996. V. 12. P. 31–33.

33. Ritskeshoitinga J., Meijers M., Timmer W.G. [et al.] Effects of 2 dietary-fat levels and 4 dietary linoleic-acid levels on mammary-tumor development in balb/c-MMTV mice under ad-libitum feeding conditions // Nutr. Cancer. 1996. V. 25. P. 72–161.

34. Mills S.C, Windsor A.C., Knight S.C. The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes // Clin. Exp. Immunol. 2005. V. 142. P. 216–228.

35. Mayser P., Grimm H., Grimminger F. n-3 Fatty acids in psoriasis // Nutr. 2002. V. 87. P. 77–82.

36. Takatsuka H., Takemoto Y., Wakae T., Mori A., Okada M., Iwata N., Okamoto T., Kanamaru A., Kakishita E. Oral eicosapentaenoic acid for acute colonic graft-versus-host disease after bone marrow transplantation // Drugs Exp. Clin. Res. 2002. V. 28. P. 121–125.

37. Goldberg R.J., Katz J.A. Meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid suplementation for inflammatory joint pain // Pain. 2007. V. 129. P. 5–7.

38. Calder P.C. n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases //Am. J. Clin. Nutr. 2006. V. 83. P. 1505–1519.

39. Shaikh S.R., Edidin M. Polyunsaturated fatty acids and membrane organization: Elucidating mechanisms to balance immunotherapy and susceptibility to infection // Chem. Phys. Lipids. 2008. V. 153. P. 24–33.

40. Anderson M., Fritsche K.L. (n-3) Fatty acids and infectious disease resistance // Nutr. 2002. V. 132. P. 3566–3576.

41. Stubbs C.D., Smith A.D. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function // Biochim. Biophys. Acta. 1984. V. 779. P. 89–137.

42. Stillwell W., Wassall S.R. Docosahexaenoic acid: membrane properties of a unique fatty acid // Chem. Phys. Lipids. 2003. V. 126. P. 1–27.

43. Belch J.J.F., Hill A. Evening primrose oil and borage oil in rheumatologic conditions // Clin. Nutr. 2000. V. 71. P. 352–356.

44. Nakamura M.T., Cheon Y., Li Y., Nara T.Y. Mechanisms of regulation of gene expression by fatty acids // Lipids. 2004. V. 39. P. 1077–1083.

45. Zeyda M., Stulnig T.M. Lipid rafts & Co.: An integrated model of membrane organization in T‑cell activation // Prog. Lipid Res. 2006. V. 45. P. 187–202.

46. Ingold K.V., Cheeseman K.H., Burton G.W. Lipid peroxidation and lipid antioxidation in normal and tumour cells // Toxicol. Pathol. 1984. V. 12. P. 229–235.

47. Begin M.E., Ells G., Das U.N., Horrobin D.F. Polyunsaturated fatty acids induced cytotoxicity against tumor cells and its relationship to lipid peroxidation // Cancer. 1988. V. 80. P. 188–194.

48. Horrobin D.F. Fatty-acid metabolism in health and disease – the role of D‑6‑desaturase // Clin. Nutr. 1993. V. 5. P. 727–732.

49. Grammatikos S., Harvey M.J., Subbaiah P.V. Loss of fatty-acid D5‑6 desaturating ability in human mammary epithelial-cells that express an activated c-Ha-ras oncogene // Oncol. 1995. V. 6. P. 1036–1039.

50. Cheeseman K.H. Lipid peroxidation and cancer. – Sussex, UK: Ellis Horwood, 1993. P. 109–144.

51. Ells G.W., Chisholm K.A., Simmons V.A., Horrobin D.F. Vitamin-E blocks the cytotoxic effect of g-linolenic acid when administered as late as the time of onset of cell-death insight into the mechanism of fatty-acid induced cytotoxicity // Cancer Lett. 1996. V. 98. P. 199–207.

52. Kokura S., Yoshikawa T., Kaneko T. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma // Cancer Res. 1997. V. 57. P. 2192–2200.

53. Newman M.J. Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor is dependent on the presence of polyunsaturated fatty acids // Proc. Natl. Acad. Sci. USA. 1990. V. 87. P. 5537–5543.

54. Kasayama S., Koga M., Kouhara H., Unsaturated fatty-acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth-factor family proteins // Cancer Res. 1994. V. 54. P. 6435–6441.

55. Zilstra J.G., De Vries E.G., Muskiet F.J. Influence of docosahexaenoic acid in vitro on intracellular adriamycin concentration in lymphocytes and human adriamycin-sensitive and resistant small cell lung cancer cell lines, and on cytoxicity in the tumour cell lines // Cancer. 1987. V. 40. P. 846–850.

56. Davies C.L., Duffy P.M., Macrobert A.J. Localization of anthracycline accumulation in sensitive and resistant urothelial tumor-cell lines //Cancer Detect. Prevent. 1996. V. 20. P. 623–625.


For citations:

Groza N.V., Golovanov A.B., Nalivayko E.A., Myagkova G.I. Therapeutic role of polyunsaturated fatty acids and of their derivatives in pathophysiological processes. Fine Chemical Technologies. 2012;7(5):3-16. (In Russ.)

Views: 235

ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)