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Tetravalent neoglycoсonjugate based on the d-galactose for medicine purposes

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Abstract

Previously, the scheme of the preparation of a tetravalent neoglycoconjugate with the terminal residues of D-galactose and with a branching component based on D-galactose was carried out in our laboratory. It includes the synthesis of hydrophilic and hydrophobic components, the synthesis of the branching scaffold and its conjugation with a hydrophilic component. This article describes the optimization of the synthesis of 1-O-azidoethyl-β-D-galactopyronaside using the change of different parameters such as temperature, solvent and reaction time. The structure of obtained glycoconjugates has potential to be capable to anti-adhesion and target delivery to certain cell group.

About the Authors

A. I. Magasumova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. D. Shuina
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


Yu. L. Sebyakin
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


U. A. Budanova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


I. S. Shchelik
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


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For citation:


Magasumova A.I., Shuina E.D., Sebyakin Yu.L., Budanova U.A., Shchelik I.S. Tetravalent neoglycoсonjugate based on the d-galactose for medicine purposes. Fine Chemical Technologies. 2015;10(4):22-26. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)