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Lanthanum Complex with Neridronic Acid: Synthesis and Properties

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Currently, various amino bisphosphonates are widely used in the treatment of many bone diseases. One of the most well-known complex compounds of neridronic acid (6-amino-1-hydroxyhexylidene-1,1- bisphosphonic acid) is sodium neridronate – a bisphosphonate, which is used to treat osteogenesis and Paget's disease. However, there is no data on compounds of neridronic acid with rare earth elements. A new complex of lanthanum with 6-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (I) was obtained and characterized by various physicochemical methods (chemical analysis, IR spectroscopy, solid-phase 31P NMR spectroscopy, optical microscopy, PCA, DTA). According to the research data the complex I has the composition {La[(H3N-(CH2)5-C(OH)(PO2(OH))2]2(H2O)2}[OH]·H2O and represents the coordination 1D-polymer due to two bridged phosphonic groups with lanthanum atoms in a tetragonal-antiprismatic environment. In a crystal, polymer chains form a 3D-frame porous structure by means of strong hydrogen bonds O─H ··· O and N─H ··· O with endless channels, available to include a variety of inorganic anions or small organic molecules. A study under the microscope showed that the sample is needle crystals (thin rods) of different lengths. The particle size distribution was obtained by laser diffraction, and the average particle size was determined: 50 µm in length and 2.5 µm in thickness.

About the Authors

A. V. Galantsev
MIREA – Russian Technological University, Moscow, 119571, Russia; LLC Skybiochem, Moscow oblast, Korolev, 141090, Russia
Russian Federation

Postgraduate Student, K.A. Bolshakov Chair of Chemistry and Technology of Rare and Scattered Elements, Nanoscale and Composite Materials, M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University; Deputy General Director of LLC Skybiochem

86, Vernadskogo pr., Moscow, 119571, Russia

2, Mayakovsky St., microdistrict Yubileiny, Korolev, Moscow region, 141090, Russia

D. V. Drobot
MIREA – Russian Technological University, Moscow, 119571, Russia
Russian Federation

D.Sc. (Chemistry), Professor, K.A. Bolshakov Chair of Chemistry and Technology of Rare and Dispersed Elements, Nanoscale and Composite Materials

86, Vernadskogo pr., Moscow 119571, Russia

P. V. Dorovatovsky
National Research Center Kurchatov Institute, Moscow, 123182, Russia
Russian Federation

Deputy Head of the Department of Synchrotron Experimental Stations of the Kurchatov Complex of Synchrotron Radiation and Nanotechnologies

1, Akademika Kurchatova sq.., Moscow, 123182, Russia

V. N. Khrustalev
National Research Center Kurchatov Institute, Moscow, 123182, Russia; Peoples' Friendship University of Russia (RUDN), Moscow, 117198, Russia
Russian Federation

D.Sc. (Chemistry), Head of the Chair of Inorganic Chemistry, Peoples’ Friendship University of Russia (RUDN), Director of the Joint Institute of Chemical Research of RUDN

6, Miklukho-Maklaya st., Moscow, 117198, Russia


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Supplementary files

1. Fig. 3. Elementary link of the polymer complex I. Bond lengths and valence angles: La1─O1 2.466(3) Å, La1─O4 2.485(3) Å, La1─O2 2.510(3) Å, P1─O1 1.528(3) Å, P1─O2 1.529(3) Å, P2─O4 1.518(3) Å, O1─La1─O4 73.01(9)°, O1─La1─O2 152.85(9)°, O4─La1─O2 76.57(9)
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2. Fig. 4. The structure of the coordination polymer I.
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3. Fig. 5. Projection of the crystal structure of lanthanum neridronate along the crystallographic b axis.
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For citation:

Galantsev A.V., Drobot D.V., Dorovatovsky P.V., Khrustalev V.N. Lanthanum Complex with Neridronic Acid: Synthesis and Properties. Fine Chemical Technologies. 2019;14(2):70-77. (In Russ.)

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ISSN 2686-7575 (Online)