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Screening of medicinal plant extracts in Vietnam and investigation of their combination for preventing and treating gout

https://doi.org/10.32362/2410-6593-2023-18-1-38-47

Abstract

Objectives. The study aimed to examine the potential use of ethanol extracts of four medicinal plants to prevent and treat gout disease.
Methods. An investigation of some typical compound contents such as polyphenols, flavonoids, and tannins in terms of two bioactive abilities, including anti-xanthine oxidase and antioxidant was carried out in Eclipta prostrata L., Artemisia vulgaris L., Apium graveolens L., and Piper betle L samples. Subsequently, the weight ratios of Piper betle L. and Artemisia vulgaris L. were investigated to reduce the total tannin content and get the most suitable anti-xanthine oxidase activity.
Results. As well as having the highest target compound contents, Piper betle L. demonstrated the best anti-xanthine oxidase and antioxidant abilities even while its IC50 values were lower than positive control; however, its high total tannin content can cause some side effects. A mixture with a weight ratio of 1:1 of Piper betle L. and Artemisia vulgaris L. had a total tannin content half that of Piper betle L. as well as demonstrating potential anti-xanthine oxidase and antioxidant activities when IC50 was about 3.94 and 20.85 µg/mL, respectively.
Conclusions. Out of the four selected plants, Piper betle L. demonstrated the best potential material for preventing and treating gout disease. However, due to the high tannin content in it, a mix of Piper betle L. and Artemisia vulgaris L. at a weight ratio of 1:1 gave optimal results for application in treatment.

About the Authors

C. Ha Anh
Ho Chi Minh City University of Technology; Vietnam National University Ho Chi Minh City
Viet Nam

Anh C. Ha, PhD, Doctor of Medicinal Chemistry, Faculty of Chemical Engineering

268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City

Linh Trung Ward, Thu Duc District, Ho Chi Minh City

Scopus Author ID 56485522100


Competing Interests:

 

 



M. Le Tan
Ho Chi Minh City University of Technology; Vietnam National University Ho Chi Minh City
Viet Nam

Tan M. Le, Postgraduate Student, Faculty of Chemical Engineering

268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City

Linh Trung Ward, Thu Duc District, Ho Chi Minh City

Scopus Author ID 57220162555, ResearcherID GWC-6849-2022

 



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Supplementary files

1. Extraction efficiencies of four studied plants
Subject
Type Исследовательские инструменты
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Indexing metadata ▾
  • The extracts of four plants were characterized by the determination of the total polyphenol content, total flavonoid content, total tannins content, and xanthine oxidase inhibitory and antioxidant activities.
  • Piper betle had significant xanthine oxidase inhibitory and antioxidant activities.
  • The weight mix of Piper betle L.and Artemisia vulgaris L. with a ratio of 1:1 give the most reasonable results that can be applied in the treatment.

Review

For citations:


Anh C.H., Tan M.L. Screening of medicinal plant extracts in Vietnam and investigation of their combination for preventing and treating gout. Fine Chemical Technologies. 2023;18(1):38-47. https://doi.org/10.32362/2410-6593-2023-18-1-38-47

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