Synthesis and properties of (±)-trans-2-dialkylaminoethylaminocyclohexanols.
Abstract
This article is devoted method of synthesis and study of the properties of (±)-trans-2- dialkylaminoethylaminocyclohexahols. It was found that the studied compounds are not toxic and have expressed antiarrhythmic properties. It was found that the explored compounds are low-toxicity substances having pronounced antiarrhythmic properties.
About the Authors
Vu Hon ShonRussian Federation
N. Yu. Borisova
Russian Federation
E. Yu. Afanasieva
Российский кардиологический научно-производственный комплекс МЗ РФ
Russian Federation
Russian Federation
G. A. Fomicheva
Российский кардиологический научно-производственный комплекс МЗ РФ
Russian Federation
Russian Federation
T. P. Kolobova
Russian Federation
E. Ya. Borisova
Russian Federation
References
1. Bergmeier, S. C. The synthesis of vicinal amino alcohols / S. C. Bergmeier // Tetrahedron. – 2000. – Vol. 56. – P. 2561–2576.
2. Машковский, М. Д. Лекарственные средства / М. Д. Машковский. – М. : Новая волна, 2002. – Т. 1 – 608 с.; Т. 2 – 539 с.
3. Joshi, N. N. Enantioselective ring cleavage of meso-epoxides with B-halodiisopinocampheyl-boranes / N. N. Joshi, M. Srebnik, H. C. Brown // J. Am. Chem. Soc. – 1988. – Vol. 110. – P. 6246–6248.
4. Jacobs, G. A. Synthesis of SQ-32,829, a new nucleoside antiviral agent / G. A. Jacobs, J. A. Tino, R. Zahler // Tetrahedron Lett. – 1989. – Vol. 30. – P. 6955–6958.
5. Jung, M. E. Efficient total synthesis of racemic and optically active cyclobut-A and simple analogues/ M. E. Jung, A. W. Sledeski // J. Chem. Soc., Chem. Commun. – 1993. – P. 589.
6. Gauvry, N. Selective synthesis of a novel methylenecyclobutane nucleoside analogue / N. Gauvry, L. Bhat, L. Mevellec, M. Zucco, F. Huet // Eur. J. Org. Chem. – 2000. – P. 2717–2722.
7. Zhou, J. A convenient synthesis of racemic 2′-deoxy carbocyclic thymidines lacking the 5′- methylene group / J. Zhou, P.B. Shevlin // Tetrahedron Lett. – 1998. – Vol. 39. – P. 8373–8376.
8. Hauser, F. M. Total synthesis of (–)-(9R)-7,11-dideoxy-13-deoxodaunomycinone / F. M. Hauser, R. A. Tommasi // J. Org. Chem. – 1991. – Vol. 56. – P. 5758–5759.
9. Synthesis and pharmacological evaluation of novel amino-prostanoids: potent and orally effective thromboxane A2 receptor antagonists / I. B. Campbell, E. W. Collington, H. Finch, P. Hallett, R. Hayes, P. Lumles, C. S. Mills, B. P. White // Bioorg. Med. Chem. Lett. – 1991. – P. 689–694.
10. Total synthesis of hemibrevetoxin B / K. C. Nicolaou, K. R. Reddy, G. Skokotas, F. Sato, Xiao Yi Xiao // J. Am. Chem. Soc. – 1992. – Vol. 114 . – P. 7935–7936.
11. Hawkins, L. R. Ammonolysis of 1,2-epoxycyclohexane and trans-2-bromocyclohexanol / L. R. Hawkins, R. A. Bannard // Can. J. Chem. – 1958. – Vol. 36. – P. 220.
12. Беркенгейм, А. М. Практикум по синтетическим лекарственным и душистым веществам и фотореактивам / А. М. Беркенгейм. – М. : Гос. научно-техн. изд-во хим. литературы, 1942. – 34 с.
For citation:
Shon V.H., Borisova N.Yu., Afanasieva E.Yu., Fomicheva G.A., Kolobova T.P., Borisova E.Y. Synthesis and properties of (±)-trans-2-dialkylaminoethylaminocyclohexanols. Fine Chemical Technologies. 2008;3(2):94-98. (In Russ.)
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