Preview

Fine Chemical Technologies

Advanced search

Synthesis of the glycerophospholipids with polymerizable groups for the stable nanoparticles formation.

Full Text:

Abstract

Synthesis of 1,2-di-(11,13-tetradecadienoyl)-sn-glycero-3-phosphocholine and 1,2-di- (2,4-hexadienoyl)-sn-glycero-3-phosphocholine, containing terminal polymerizable diene groups has been carried out. It is supposed that using of synthesized phosphorlipids mixtures followed by their polymerization will lead to formation of stable nanoparticles – bicelles, which will be capable to exist in a wide range of concentration of mixed components and resistant to organic solvents action.

About the Authors

N. A. Bragina

Russian Federation


I. N. Fedulova

Russian Federation


I. P. Ushakova

Russian Federation


P. V. Dubovskij

Russian Federation


V. V. Chupin

Russian Federation


References

1. Everts, S. H-1 and C-13 NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids / S. Everts, J. H. Davis // Biophys. J. – 2000. – Vol. 79. – P. 885–897.

2. Current applications of bicelles in NMR studies of membrane-associated amphiphiles and proteins / R. S. Prosser [et al.] // Biochemistry. – 2006. – Vol. 45, № 28. – P. 8453–8463.

3. Marcotte, I. Bicelles as model membranes for solid- and solution-state NMR studies of membrane peptides and proteins / I. Marcotte, M. Auger // Concepts Magn. Reson., Part A. – 2005. – Vol. 24. – P. 17–37.

4. Singh, A. Polymerizable phospholipids. In Phospholipids Handbook / A. Singh, J. Schur, G. Cevc. Ed. M. Dekker. – New York, 1993. – P. 223–291.

5. Химия липидов / Р. П. Евстигнеева [и др.] – М. : Химия, 1983. – С. 161–162.

6. Брагина, Н. А. Методы синтеза дейтеромеченых липидов / Н. А. Брагина, В. В. Чупин // Успехи химии. – 1997. – Т. 66. – С. 1077–1090.

7. Phospholipids polymers – synthesis and spectral characteristics / D. S. Johnston [et al.] // Biochim. Biophys. Acta. – 1980. - Vol. 602, № 1. – P.183–187.

8. Синтез фосфатидилхолинов с остатками способных к полимеризации жирных кислот / А. В.Аникин [и др.] // Биоорган. химия. – 1990. – Т. 16, № 2.– С. 254– 261.

9. Hoye, T. R. 3,5-Hexadienoic esters: a convenient preparation / T. R. Hoye, A. Magee, S. Trumper // Synth. Commun. – 1982. – Vol. 12, № 3. – P. 183–187.


For citation:


Bragina N.A., Fedulova I.N., Ushakova I.P., Dubovskij P.V., Chupin V.V. Synthesis of the glycerophospholipids with polymerizable groups for the stable nanoparticles formation. Fine Chemical Technologies. 2008;3(2):74-78. (In Russ.)

Views: 53


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)