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Synthesis and easy intramolecular cyclization in a number of aspartyl derivatives of histamine

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Abstract

A series of natural and novel aspartyl derivatives of histamine were obtained by the classical peptide chemistry methods in a solution. During the synthesis of Nacetylaspartylhistamine easy and spontaneously cyclization of the protected Ac-AspOBzl into succinimide derivative was observed even after one day storage.

About the Authors

G. A. Zheltukhina
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. I. Efimova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


T. A. Kromova
ООО «Фарминтерпрайсез»
Russian Federation


V. E. Nebolsin
ООО «Фарминтерпрайсез»
Russian Federation


References

1. J. Borycz, J.A. Borycz, M. Loubani and I.A Meinertzhagen, //J. Neurosci. – 2002. –

2. Vol. 22. - P. 10549.

3. B.A. Battelle, M.K. Hart. //Comparative Biochemistry and physiology. – 2002. –

4. Vol.133. – P.135.

5. H. Konishi, Y. Kakimoto. //J. Neurochem. – 1976. – Vol.27 – P.1461-1463.

6. E. Kvamme, K.L. Reichelt, P.D. Edminson. //Proceedings of the tenth FEBS meeting.

7. – 1975. – P. 127-136.

8. K.L. Reichelt, E. Wedege, E Kvamme. //J. Neurochem. – 1971. – Vol 18. – P.2129-

9.

10. K.L. Reichelt, E. Kvamme. //J. Neurochem. – 1973. – Vol. 21 – P.849.

11. V.E.Nebolsin, G.A. Zheltukhina, V.V. Krzechkovskaya, V.L. Kovaleva,

12. R.P.Evstigneeva. //Vopr. Med. Chem. – 2001. – Vol. 47 – P.301-307.

13. Э.Гросс, И.Майенхофер E. Основные методы образования пептидных связей. – М.:

14. Мир, 1983. – 421 с.

15. M.A. Ondetti, A. Deer, T. Sheehan et al. //Biochemistry. – 1968. – Vol. 7 – P. 4069-

16.


For citation:


Zheltukhina G.A., Efimova E.I., Kromova T.A., Nebolsin V.E. Synthesis and easy intramolecular cyclization in a number of aspartyl derivatives of histamine. Fine Chemical Technologies. 2006;1(4):39-43. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)