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Chemical synthesis of ω- hydroxyderivatives of plant fatty acid substrates.

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Abstract

A common synthetic procedure for the synthesis of (9Z,12Z)-18-hydroxy-9,12- octadecadienoic acid (18-HODE) and (9Z,12Z,15Z)-18-hydroxy-9,12,15- octadecatrienoic acid (18-HOTrE) – analogues of substrates of plant lipids oxygenation was developed. The synthetic route is based on formation of polyacetylenic precursors followed by stereoselective reduction of the triple bonds on Lindlar’s catalyst.

About the Authors

N. V. Groza
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


I. V. Ivanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


A. B. Golovanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


G. I. Myagkova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


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For citation:


Groza N.V., Ivanov I.V., Golovanov A.B., Myagkova G.I. Chemical synthesis of ω- hydroxyderivatives of plant fatty acid substrates. Fine Chemical Technologies. 2006;1(4):29-32. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)