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The synthesis of galactose-containing amphiphiles

Abstract

The synthesis of galactose-containing amphiphiles based on tetradecanol, cholesterol or 1,2-di-O-tetradecylglycerol has been described. The compounds synthesized can be used as components of liposomal targeted carries for therapeutics delivery into liver cells.

Keywords


547.455.627:547.426.2'268.17:547.922:547.233.4

About the Authors

Е. А. Ivanova
МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86
Russian Federation

Competing Interests: M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571


N. G. Morozova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


М. М. Maslov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


G. A. Serebrennikova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. Lindhorst, T. Artificial multivalent sugar ligands to understand and manipulate carbohydrate-protein interaction / Т. Lindhorst // Top. Curr. Chem. - 2002. - Vol. 218. - P. 201-235.

2. Carbohydrate-encapsulated gold nanoparticles for rapid target-protein identification and binding epitope mapping/ Y. Chen [et al.] // ChemBioChem. - 2005. - Vol. 6. - P. 1169-1173.

3. Synthesis of polyanionic glycopolymers for the facile assembly of glycosyl arrays / H. Uzawa [et al.] // Tetrahedron. - 2005. - Vol. 61. - P. 5895-5905.

4. Gold nanoparticles with different capping systems: an electronic and structural XAS analysis / C. Lopez-Cartes [et al.] / J. Phys. Chem. - 2005. - Vol. 109. - P. 8761-8766.

5. Targeting cell surface receptors with ligand-conjugated nanocrystals / S. Rosental [et al.] // J. Am. Chem. Soc. - 2002. - Vol. 124. - P.4586-4594.

6. New synthetic glycolipids for targeted gene transfer: synthesis, formulation in lipoplexes and specific interaction with lectin / M. Carriere [et al.] // Drug Delivery. - 2004. - Vol. 11. - P. 351-363.

7. Synthesis and formulation of neoglycolipids for the functionalization of liposomes and lipoplexes / E. Perouzel [et al.] // Bioconjugate Chem. - 2003. - Vol. 14. - P. 884-898.

8. Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver / R. Mukthavaram [et al.] // Biomaterials. - 2009. - Vol. 30. - P. 2369-2384.

9. Oligomethylene spacer length dependent interaction of synthetic galactolipids incorporated in phospholipid layers with ricin / H. Tamiaki [et al.] // Colloids and Surfaces B: Biointerfaces. - 2006. - Vol. 53. - P. 87-93.

10. Preparation and applications of 2-bromoethyl glycosides: synthesis of spacer-arm glycosides and agglutination inhibitors/ J. Dahmen [et al/] // Carbohyd. Res. - 1982. - Vol. 111. - P. 1-4.

11. Синтез 1,2-ди-О-алкилглицеринов с использованием аллильной защитной группы / М. В. Аникин, И. П. Ушакова, Г. А. Серебренникова, Р. П. Евстигнеева // Черкассы, 1987. - Деп. ОНИИТЭИХим, № 915-хп87.


Review

For citations:


Ivanova Е.А., Morozova N.G., Maslov М.М., Serebrennikova G.A. The synthesis of galactose-containing amphiphiles. Fine Chemical Technologies. 2010;5(5):65-70. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)