Preview

Fine Chemical Technologies

Advanced search

Liposomal form of desferal as an effective chlamidial agent

Full Text:

Abstract

Des f eral is a free iron ions blocker used for heart attacks and strokes treatment for more than 30 years. In several in vitro studies it was also shown that desferal concentrations of 15–100 mM cause shortage of iron in Chlamydia pneumoniae and Chlamydia trachomatis, affecting these bacteria growth and development. The main problems of this compound for treatment of chlamydia are its toxicity and low ability to pass through the cell membrane. In this research the in vitro toxicity and activity of desferal encapsulated in soybean phosphatidyl - choline liposomes were studied. It was demonstrated that the liposomal form of the chelator is less toxic and more active as compared to its solution.

About the Authors

N. V. Rukosueva
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. A. Zakharova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. A. Bezrykov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


A. P. Kaplun
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. I. Shvets
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


N. A. Zigangirova
ГУ НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН
Russian Federation


References

1. Карягина А.С., Алексеевский А.В., Спирин С.А., Зигангирова Н.А., Гинцбург А.Л. Эффекторные белки хламидий // Мол. биология. 2009. Т. 43. Вып. 6. С. 963–983.

2. Dean D. Chlamydia trachomatis today: Treatment, detection, immunogenetics and the need for a greater global understanding of chlamydial disease pathogenesis // Drugs Today. 2009. V. 25 (supple B). P. 25–31.

3. Raulston J. E. Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins // Infect. Immun. 1999. V. 65. P. 4539–4547.

4. Chaston T.B., Richardson R. Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity // Amer. J. Hematology. 2003. V. 73. P. 200–210.

5. Al-Younes H.M., Rudel T., Brinkmann V., Szczepek A.J., Meyer T.F. Low iron availability modulates the course of Chlamydia pneumoniae infection // Cell. Microbiol. 2001. V. 3. № 6. P. 427–437.

6. Kim H.J., Hida H., Jung C.G., Miura Y., Nishino H. Treatment with deferoxamine increases neurons from neural stem/progenitor cells // Brain Res. 2006. V. 1092. № 1. P. 1–15.

7. Швец В.И., Каплун А.П., Краснопольский Ю.М., Степанов А.Е., Чехонин В.П. От липосом семидесятых к наночастицам XXI века // Рос. нанотехнологии. 2008. Т. 3. № 11-12. С. 6–20.


For citation:


Rukosueva N.V., Zakharova D.A., Bezrykov D.A., Kaplun A.P., Shvets V.I., Zigangirova N.A. Liposomal form of desferal as an effective chlamidial agent. Fine Chemical Technologies. 2012;7(6):22-26. (In Russ.)

Views: 50


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)