Preview

Fine Chemical Technologies

Advanced search

DEVELOPMENT OF MICROREACTOR METHOD FOR POLYMERIC MICROSPHERES PRODUCTION USED IN TEST SYSTEMS BASED ON LATEX AGGLUTINATION REACTION

Full Text:

Abstract

Some steps were taken to elaborate a method for the preparation of polymeric microspheres using flow microreactors by emulsifying the solution of methacrylic acid esters copolymer in an aqueous PVA solution followed by extraction and evaporation of the solvent. The effect of process parameters on the characteristics of polymeric microspheres with a predetermined set of properties (mean size, polydispersity) potentially suitable for use as carriers in bioligands for diagnostic test systems was investigated. The dependence of the average particle size on the microreactor type, concentration of copolymer solution in methylene chloride and polyvinyl alcohol in water and the ratio of flow rates of organic and aqueous phases was stated, and the optimal process conditions were selected.

About the Authors

S. A. Kedik
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. A. Petrova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. S. Zhavoronok
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


A. V. Panov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. V. Suslov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. Солодухина Н.М. Анализ опиатов, барбитуратов и каннабиоидов методом латексной агглютинации с использованием функциональных полимерных микросфер : дис. … канд. хим. наук. - М., 2012. 114 с.

2. Артыкова З.Б., Грицкова И.А., Гусев С.А., Басырева Л.Ю., Сочилин В.А., Штильман М.И., Горячая А.В., Хейнман Г.П., Кедик С.А., Прокопов Н.И. Получение диагностических тест-систем на основе полимерных микросфер в присутствии поливинилпирролидона, модифицированного аминокислотой // Вестник МИТХТ. 2010. Т. 5. № 3. С. 82-87.

3. Ahmad H., Oli M.W.U., Ali A.M.I., Miah M.A.J. Preparation of sub-micron to micron-sized di-functional polymer particles and their characterization// Malaysian Polymer J. 2010. V. 5. № 2. P. 181-192.

4. Петрова Е.А., Кедик С.А., Алексеев К.В., Блынская Е.В., Панов А.В., Суслов В.В., Тихонова Н.В. Оценка эффективности метода двойного эмульгирования при получении микросфер налтрексона на основе сополимера молочной и гликолевой кислот // Вестник МИТХТ. 2013. Т. 8. № 2. С. 58-63.

5. Ekanem E.E., Shiu Y.Y., Tauanov Z., Sharma L., Shahmohamedi H., Henry J.V., Das D., Vladisavljević G.T. Development of novel drug formulation using microfluidic device / Technology Forum 2012 «Formulating with particles». - Loughborough University, April 4-5, 2012.

6. Martín-Banderas B.L., Rodríguez-Gil A., Cebolla Á., Chávez S., Berdún-Álvarez T., Fernandez G.J.M., Flores-Mosquera M., Gañán-Calvo A.M. Towards high-throughput production of uniformly encoded microparticles// Advanced Material. 2006. V. 18. P. 559-564.


For citation:


Kedik S.A., Petrova E.A., Zhavoronok E.S., Panov A.V., Suslov V.V. DEVELOPMENT OF MICROREACTOR METHOD FOR POLYMERIC MICROSPHERES PRODUCTION USED IN TEST SYSTEMS BASED ON LATEX AGGLUTINATION REACTION. Fine Chemical Technologies. 2013;8(4):11-17. (In Russ.)

Views: 66


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)