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DEVELOPMENT OF MICROREACTOR METHOD FOR POLYMERIC MICROSPHERES PRODUCTION USED IN TEST SYSTEMS BASED ON LATEX AGGLUTINATION REACTION

Abstract

Some steps were taken to elaborate a method for the preparation of polymeric microspheres using flow microreactors by emulsifying the solution of methacrylic acid esters copolymer in an aqueous PVA solution followed by extraction and evaporation of the solvent. The effect of process parameters on the characteristics of polymeric microspheres with a predetermined set of properties (mean size, polydispersity) potentially suitable for use as carriers in bioligands for diagnostic test systems was investigated. The dependence of the average particle size on the microreactor type, concentration of copolymer solution in methylene chloride and polyvinyl alcohol in water and the ratio of flow rates of organic and aqueous phases was stated, and the optimal process conditions were selected.

About the Authors

S. A. Kedik
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. A. Petrova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. S. Zhavoronok
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


A. V. Panov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. V. Suslov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

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Review

For citations:


Kedik S.A., Petrova E.A., Zhavoronok E.S., Panov A.V., Suslov V.V. DEVELOPMENT OF MICROREACTOR METHOD FOR POLYMERIC MICROSPHERES PRODUCTION USED IN TEST SYSTEMS BASED ON LATEX AGGLUTINATION REACTION. Fine Chemical Technologies. 2013;8(4):11-17. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)