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TECHNOLOGY FOR TEST-SYSTEMS FOR DIAGNOSIS OF MODIFIED PROTEINS (PROTEOPATHY) UNDERLYING SOCIAL DISEASES (Report 2)

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Abstract

A high-tech technology for highly sensitive test systems is proposed based on conjugates "polymer microsphere-bioligand" for express diagnosis of autoantibodies to the modified protein (proteopathy) for example, thyroglobulin, using the method of latex agglutination reaction (in vitro).

About the Authors

Ya. M. Stanishevskiy
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Department of Biomedical and Pharmaceutical Technology,  associate professor


I. A. Gritskova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Department of Chemical Technology of Macromolecular Compounds, professor


A. V. Fedorova
National University Lviv Polytechnic, 79013, Lviv
Ukraine
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology,  associate professor


V. P. Novikov
National University Lviv Polytechnic, 79013, Lviv
Ukraine
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, professor


References

1. Bykov V.A., Gritskova I.A., Prokopov N.I., Stanishevsky Ya.M. Polymer microspheres in diagnostics. - M.: Tutorial, 2004.

2. Abdoel T.H., Smits H.L. Rapid latex agglutination test for the serodiagnosis of human brucellosis // Diagnostic Microbiology & Infectious Disease. 2007. V. 57. P. 123-128.

3. Borel T., Rose AMC, Guillerm M., Sidikou F., Gerstl S., Djibo A., Nathan N., Chanteau S., Guerin P.J. High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitides serogroup A during a clinical trial in Niger // Trans. Royal Soc. Tropical Medicine & Hygiene. 2006. V. 100. P. 964-969.

4. Fernandez-Rodrıguez A., Vazquez J.A., Suarez-Mier M.P., Aguilera B., Ballesteros S., De la Fuente L., Vallejo G., Sancho M. Latex agglutination for bacterial antigens and meningococcus PCR: Two useful tools in legal sudden deaths // Forensic Sci. Int. 2005. V. 147. P. 13-20.

5. Turton M., Banghem D.R., Kolkott K.A. New methods of immunoassay. - Academic Press, 1991. P. 116.

6. Frimel G. Immunological methods. - M.: Nauka, 1987. P. 89-96.

7. Yalow R.S. Radioimmunoassay // Annu Rev. Biophys. Bioeng. 1980. V. 9. P. 327.

8. Egorov A.M., Osipov A.P., Dzantiev B.B., Gavrilova E.M. Theory and practice of immunoassay. - M.: Higher School, 1991.

9. Wennig R., Moeller M.R, Haguenoer J.M. [et al.] Development and evaluation of immunochromato-graphic rapid tests for screening of cannabinoids, cocaine, and opiates in urine // J. Anal. Toxicol. 1998. V. 22. P. 148-155.

10. Prokopov N.I. Synthesis of polymeric suspensions with a narrow particle size distribution by hetero-phase polymerization : Thesis … Doc. Chem. Sci. - M., 1999.

11. Lobanov A.N. Synthesis of polymeric suspensions of biomedical destination : Thesis … PhD. Chem. Sci. - M., 2003.

12. Krasheninnikov I.G. Polymer suspension of biomedical purposes with a narrow particle size distribution: Thesis.. Doc. Chem. Sci. - M., 2007.

13. Synthetic latex SKS-65 GM (GOST 10564-75). Specifications. M.: PKI Publishers "Standards", 1999.

14. Lines R.V. Measurement of particle size distribution by autocorrelation spectroscopy // Abstracts of Int. Conf. Polymer Latex II. - London, 1985. P. 1-10.

15. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent // J. Biol. Chem. 1951. V. 193. P. 265-275.

16. Stanishevsky Ya.M. Development of diagnostic test kits "Polymer microspheres-bioligands", life sciences applications: Thesis.. Doc. Chem. Sci. - M., 2012.


For citation:


Stanishevskiy Y.M., Gritskova I.A., Fedorova A.V., Novikov V.P. TECHNOLOGY FOR TEST-SYSTEMS FOR DIAGNOSIS OF MODIFIED PROTEINS (PROTEOPATHY) UNDERLYING SOCIAL DISEASES (Report 2). Fine Chemical Technologies. 2013;8(5):77-82. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)