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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">chemicallytech</journal-id><journal-title-group><journal-title xml:lang="en">Fine Chemical Technologies</journal-title><trans-title-group xml:lang="ru"><trans-title>Тонкие химические технологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-6593</issn><issn pub-type="epub">2686-7575</issn><publisher><publisher-name>MIREA – Russian Technological University (RTU MIREA).</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">chemicallytech-532</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ</subject></subj-group></article-categories><title-group><article-title>TECHNOLOGY FOR TEST-SYSTEMS FOR DIAGNOSIS OF MODIFIED PROTEINS (PROTEOPATHY) UNDERLYING SOCIAL DISEASES (Report 2)</article-title><trans-title-group xml:lang="ru"><trans-title>TECHNOLOGY FOR TEST-SYSTEMS FOR DIAGNOSIS OF MODIFIED PROTEINS (PROTEOPATHY) UNDERLYING SOCIAL DISEASES (Report 2)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Stanishevskiy</surname><given-names>Ya. M.</given-names></name><name name-style="western" xml:lang="en"><surname>Stanishevskiy</surname><given-names>Ya. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Department of Biomedical and Pharmaceutical Technology,  associate professor</p></bio><bio xml:lang="en"><p>Department of Biomedical and Pharmaceutical Technology,  associate professor</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Gritskova</surname><given-names>I. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritskova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Department of Chemical Technology of Macromolecular Compounds, professor</p></bio><bio xml:lang="en"><p>Department of Chemical Technology of Macromolecular Compounds, professor</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Fedorova</surname><given-names>A. V.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, associate professor</p></bio><bio xml:lang="en"><p>Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology,  associate professor</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Novikov</surname><given-names>V. P.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikov</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, professor</p></bio><bio xml:lang="en"><p>Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, professor</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>National University Lviv Polytechnic, 79013, Lviv</institution><country>Украина</country></aff><aff xml:lang="en"><institution>National University Lviv Polytechnic, 79013, Lviv</institution><country>Ukraine</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2013</year></pub-date><volume>8</volume><issue>5</issue><fpage>77</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Stanishevskiy Y.M., Gritskova I.A., Fedorova A.V., Novikov V.P., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Stanishevskiy Y.M., Gritskova I.A., Fedorova A.V., Novikov V.P.</copyright-holder><copyright-holder xml:lang="en">Stanishevskiy Y.M., Gritskova I.A., Fedorova A.V., Novikov V.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.finechem-mirea.ru/jour/article/view/532">https://www.finechem-mirea.ru/jour/article/view/532</self-uri><abstract><p>A high-tech technology for highly sensitive test systems is proposed based on conjugates "polymer microsphere-bioligand" for express diagnosis of autoantibodies to the modified protein (proteopathy) for example, thyroglobulin, using the method of latex agglutination reaction (in vitro).</p></abstract><trans-abstract xml:lang="ru"><p>A high-tech technology for highly sensitive test systems is proposed based on conjugates "polymer microsphere-bioligand" for express diagnosis of autoantibodies to the modified protein (proteopathy) for example, thyroglobulin, using the method of latex agglutination reaction (in vitro).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>diagnostic test system</kwd><kwd>the polymer suspension</kwd><kwd>thyroglobulin</kwd><kwd>latex agglutination reaction</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diagnostic test system</kwd><kwd>the polymer suspension</kwd><kwd>thyroglobulin</kwd><kwd>latex agglutination reaction.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bykov V.A., Gritskova I.A., Prokopov N.I., Stanishevsky Ya.M. 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