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Analysis of difenacoum in rodenticide compositions containing derivatives coumatetralyl

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Abstract

The possibility of simultaneous determination of the title compounds and coumatetralyl derivatives (coumatetralyl, flocumaphen and brodifacoum) in rodenticide means was considered. The conditions of direct analytical determination and stages of preparation were adapted, which will provide determination of the isomeric composition of difenacoum in rodenticide compositions. Using less polar mobile phases on the basis of acetonitrile is preferable as compared to mixtures on the basis of methanol. Conditions allowing the separation of enantiomers with the limit of sensitivity of the method for difenacoum level 0.0002% were found, which allows to monitor the content of more active trans isomers of the title compound both in the original rodenticide substances and in the end poisoned baits. Implementation of the analytical stage of the determination of the isomeric composition of difenacoum involves the use of simpler equipment due to the implementation of the isocratic mode afterwards.

About the Authors

L. A. Nosikova
Moscow Technological University (Institute of Fine Chemical Technologies), 86, Vernadskogo pr., Moscow 119571
Russian Federation


A. N. Kochetov
«METTEM-Technology», 3, Parkovaya str., Balashikha, 143900
Russian Federation


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For citation:


Nosikova L.A., Kochetov A.N. Analysis of difenacoum in rodenticide compositions containing derivatives coumatetralyl. Fine Chemical Technologies. 2015;10(6):88-95. (In Russ.)

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