The use of nanodispersions prepared from birch bark extract for poor soluble substances solubilization.
Abstract
The method of poor soluble substances solubilization with the use of nanodispersions prepared from birch bark extract is proposed. Optimal substance/carrier ratios for methylpheophorbide A, doxorubicin, silymarin and silibinin have been determined.
About the Authors
V. V. Krasil’nikova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
N. I. Pakhar’kova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
V. I. Popenko
Институт молекулярной биологии им. В.А. Энгельгардта РАН
Russian Federation
Russian Federation
A. P. Kaplun
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
References
1. Соловский, М. В. Соли антибиотика гентамицина с карбоксилсодержащими сополимерами N-винилпирролидона / М. В. Соловский, Н. В. Никольская, В. М. Денисов // Хим.-фарм. журн. – 2000. – Т. 34, № 11. – С. 21–24.
2. Boas, U. Dendrimers in drug research / U. Boas, P. M. Heegaard // Chem. Soc. Rev. – 2004. – Vol. 33, № 1. – P. 43–63.
3. Wells, J. Localized delivery to CT-26 tumors in mice using thermosensitive liposomes / J. Wells, A. Sen, S. W. Hui // Int. J. Pharm. – 2003. – Vol. 261. – P. 105–114.
4. Microemulsion formation for enhanced absorption of poorly soluble drugs. I. Prescription design / K. Kawakami, T. Yoshikawa, Y. Moroto, E. Kanaoka, K. Takahashi, Y. Nishihara, K. Masuda // J. Control. Release. – 2002. – Vol. 81. – P. 65–74.
5. Study of the drug release mechanism from tyrphostin AG-1295-loaded nanospheres by in situ and external sink methods / M. Chorny, I. Fishbein, H. D. Danenberg, G. Golomb. // J. Control. Release. – 2002. – Vol .83. – P. 401–414.
6. Sahoo, S. K. Nanotech approaches to drug delivery and imaging / S. K. Sahoo, V. Labhasetwar // Drug Deliv. Today. – 2003. – Vol. 8, № 24. – P. 1112–1120.
7. Trotta, M. Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique / M. Trotta, F. Debernardi, O. Caputo // Int. J. Pharm. – 2003. – Vol. 257. – P. 153–160.
8. Gal-Fuzy, M. Cyclodextrin-stabilized volatile substances for inhalation therapy. / M. Gal-Fuzy, L. Szejtli, J. Harangi // J. Pharmazie. – 1985. – Vol. 39. – P. 558–559.
9. Lukyanov, A. N. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs / A. N. Lukyanov, V. P. Torchilin. // Adv. Drug Deliv. Rev. – 2004. – Vol. 56. – P. 1273–1289.
10. Kushida, I. Improvement of dissolution and oral absorption of ER-34122, a poorly water-soluble dual 5-lipoxygenase/cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion / I. Kushida, M. Ichikawa, N. Asakawa // J. Pharm. Sci. – 2002. – Vol. 91, № 1. – P. 258–266.
11. Preparation of clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection / K. Peters, S. Leitzke, J. E. Diederichs, K. Borner, H. Hahn, R. H. Müller, S. Ehlers // J. Antimicrob. Chemother. – 2000. – Vol. 45. – P. 77–83.
12. Машковский, М. Д. Лекарственные средства, 15-е изд. / М. Д. Машковский. – М. : РИА «Новая волна», 2007. – С. 526.
Review
For citations:
Krasil’nikova V.V., Pakhar’kova N.I., Popenko V.I., Kaplun A.P. The use of nanodispersions prepared from birch bark extract for poor soluble substances solubilization. Fine Chemical Technologies. 2008;3(5):88-92. (In Russ.)
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