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The use of copper reagents on the base of copper (I) chloride for the synthesis of trans-3-substituted cyclic a-amino acids

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Abstract

An efficient synthesis of 3-substituted cyclic amino acids via 1,4-conjugate addition of diorganocuprates to α,β-unsaturated cyclic α-aminoacids is described.The higher reactivity of copper reagents obtained from copper (I) chloride in comparison with CuCN, CuBr, CuI and CuBr*SMe2 has been shown

About the Authors

V. S. Kublitskii
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


A. E. Stepanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. M. Trukhan
ООО «Кембридж»
Russian Federation


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For citation:


Kublitskii V.S., Stepanov A.E., Trukhan V.M. The use of copper reagents on the base of copper (I) chloride for the synthesis of trans-3-substituted cyclic a-amino acids. Fine Chemical Technologies. 2006;1(5):83-86. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)