Synthesis of new 3'-N-alcyl and 3'-N-alkyl 3'-amino-3'-deoxythymidine derivatives
Abstract
A number of new 3'-N-alcyl and 3'-N-alkyl derivatives of 3'-amino-3'-deoxythymidine was obtained by means of nucleoside and carboxylic acids condensation. Also new 3'-N-alkyl derivatives of 3'-amino-3'-deoxythymidine was obtained by means of nucleoside alkylation with esters of a,b-unsaturated carboxylic acids
About the Authors
K. V. Seregin
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
N. A. Iltyakova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
M. V. Chudov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
V. I. Shvets
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
References
1. DeClercq E.//Current Medicinal Chemistry, 2001, P.1543 - 1572
2. Celewicz L., Urjasn W., Golankiewicz K.//Nucleosides & Nucleotides, 1993, v.12, №9, P.951 - 966
3. Chung K., Raymond F., Moon K., Giliyar V., Zi P..//J. Med. Chem., 1989, V.32, P.612 - 617
4. Wigerinck P., Van Aercschot A., Janssen G., Claes P.//J. Med. Chem., 1990, V.33, P.868 - 873
5. Zehl A., Cech D.//Libigs Ann., 1997, P.595 - 600
6. Handlon A., Oppenheimer N.//Pharm. Res., 1988, P.297 - 299
7. Leffler J., Temple R.//J. Am. Chem. Soc., 1967, P.5235 - 5245
8. Krenitsky T., Freeman G., Shaver S., Beacham III L., Hurlbert S//J. Med. Chem., 1983, V.26, P.891 - 895
9. Lin T., Prusoff W.//J. Med. Chem., 1978. V.21, P.109 – 112
10. Ashida N., Asano S., Kohda K.//Anticancer Res., 1994, V.14, P.2061 – 2062
11. Cretton E., Sommadossi J. //Drug Metab. Dispos., 1993, V.21, P.946 - 950
12. Maillard M., Faraj A., Frappier F., Florent J.-C., Grierson D., Monneret C//Nucleic Acids Res. Suppl., 2001, P.121 – 122
13. Pannecouque C, Van Poppel K., Balzarini J., Claes P., De Clercq E., Herdewijn P.//Nucleosides & Nucleotides, 1995, V.14, №3-5, P.541 - 544
14. Jasko M., Fedorov I., Atrazhev A.//Nucleosides & Nucleotides, 1995, V.14, №1&2, P.23 – 37
15. Hampton A., Kappler F., Chawia R//J. Med. Chem., 1979, V.22, №6, P.621 – 631.
Review
For citations:
Seregin K.V., Iltyakova N.A., Chudov M.V., Shvets V.I. Synthesis of new 3'-N-alcyl and 3'-N-alkyl 3'-amino-3'-deoxythymidine derivatives. Fine Chemical Technologies. 2006;1(1):33-37. (In Russ.)
Views:
308
Email this article 
