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Synthesis of new 3'-N-alcyl and 3'-N-alkyl 3'-amino-3'-deoxythymidine derivatives

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Abstract

A number of new 3'-N-alcyl and 3'-N-alkyl derivatives of 3'-amino-3'-deoxythymidine was obtained by means of nucleoside and carboxylic acids condensation. Also new 3'-N-alkyl derivatives of 3'-amino-3'-deoxythymidine was obtained by means of nucleoside alkylation with esters of a,b-unsaturated carboxylic acids

About the Authors

K. V. Seregin
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


N. A. Iltyakova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


M. V. Chudov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. I. Shvets
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. DeClercq E.//Current Medicinal Chemistry, 2001, P.1543 - 1572

2. Celewicz L., Urjasn W., Golankiewicz K.//Nucleosides & Nucleotides, 1993, v.12, №9, P.951 - 966

3. Chung K., Raymond F., Moon K., Giliyar V., Zi P..//J. Med. Chem., 1989, V.32, P.612 - 617

4. Wigerinck P., Van Aercschot A., Janssen G., Claes P.//J. Med. Chem., 1990, V.33, P.868 - 873

5. Zehl A., Cech D.//Libigs Ann., 1997, P.595 - 600

6. Handlon A., Oppenheimer N.//Pharm. Res., 1988, P.297 - 299

7. Leffler J., Temple R.//J. Am. Chem. Soc., 1967, P.5235 - 5245

8. Krenitsky T., Freeman G., Shaver S., Beacham III L., Hurlbert S//J. Med. Chem., 1983, V.26, P.891 - 895

9. Lin T., Prusoff W.//J. Med. Chem., 1978. V.21, P.109 – 112

10. Ashida N., Asano S., Kohda K.//Anticancer Res., 1994, V.14, P.2061 – 2062

11. Cretton E., Sommadossi J. //Drug Metab. Dispos., 1993, V.21, P.946 - 950

12. Maillard M., Faraj A., Frappier F., Florent J.-C., Grierson D., Monneret C//Nucleic Acids Res. Suppl., 2001, P.121 – 122

13. Pannecouque C, Van Poppel K., Balzarini J., Claes P., De Clercq E., Herdewijn P.//Nucleosides & Nucleotides, 1995, V.14, №3-5, P.541 - 544

14. Jasko M., Fedorov I., Atrazhev A.//Nucleosides & Nucleotides, 1995, V.14, №1&2, P.23 – 37

15. Hampton A., Kappler F., Chawia R//J. Med. Chem., 1979, V.22, №6, P.621 – 631.


For citation:


Seregin K.V., Iltyakova N.A., Chudov M.V., Shvets V.I. Synthesis of new 3'-N-alcyl and 3'-N-alkyl 3'-amino-3'-deoxythymidine derivatives. Fine Chemical Technologies. 2006;1(1):33-37. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)