Synthesis, biological properties and effects of trans-2-(substituted amino)-cyclohehyl esters.
Abstract
A series of trans-2-(substituted amino)-cyclohehyl esters have been synthesized and examined for pharmacological activity. Significant responses have been noted with these compounds as ant arrhythmic substances.
About the Authors
Vu Hon Shon
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
D. M. Zverev
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
N. Yu. Borisova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
E. Yu. Afanasieva
Российский кардиологический научно-производственный комплекс МЗ РФ
Russian Federation
Russian Federation
T. P. Kolobova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
E. Ya. Borisova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
References
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2. Пат. 6174879 США. Aminocyclohexylesters and uses thereof. / B. A. MacLeod, M. J. A. Walker, R. A. Wall // РЖХим. – 2001. – 01.22-19О.55П.
3. Hawkins, L. R. Ammonolysis of 1,2-epoxycyclohexane and trans-2-bromocyclohexanol / L. R. Hawkins, R. A. Bannard R. A. // Can. J. Chem. – 1958. – Vol. 36. – P. 220.
4. Freed, V. H. Preparation and reactions of 2,4-dichlorophenoxy-acethyl chloride / V. H. Freed // J. Am. Chem. Soc. – 1946. – Vol. 68. – P. 2112.
Review
For citations:
Shon V.H., Zverev D.M., Borisova N.Yu., Afanasieva E.Yu., Kolobova T.P., Borisova E.Y. Synthesis, biological properties and effects of trans-2-(substituted amino)-cyclohehyl esters. Fine Chemical Technologies. 2007;2(6):85-89. (In Russ.)
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