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Synthesis, biological properties and effects of trans-2-(substituted amino)-cyclohehyl esters.

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Abstract

A series of trans-2-(substituted amino)-cyclohehyl esters have been synthesized and examined for pharmacological activity. Significant responses have been noted with these compounds as ant arrhythmic substances.

About the Authors

Vu Hon Shon
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. M. Zverev
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


N. Yu. Borisova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. Yu. Afanasieva
Российский кардиологический научно-производственный комплекс МЗ РФ
Russian Federation


T. P. Kolobova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


E. Ya. Borisova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571


References

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2. Пат. 6174879 США. Aminocyclohexylesters and uses thereof. / B. A. MacLeod, M. J. A. Walker, R. A. Wall // РЖХим. – 2001. – 01.22-19О.55П.

3. Hawkins, L. R. Ammonolysis of 1,2-epoxycyclohexane and trans-2-bromocyclohexanol / L. R. Hawkins, R. A. Bannard R. A. // Can. J. Chem. – 1958. – Vol. 36. – P. 220.

4. Freed, V. H. Preparation and reactions of 2,4-dichlorophenoxy-acethyl chloride / V. H. Freed // J. Am. Chem. Soc. – 1946. – Vol. 68. – P. 2112.


For citation:


Shon V.H., Zverev D.M., Borisova N.Yu., Afanasieva E.Yu., Kolobova T.P., Borisova E.Y. Synthesis, biological properties and effects of trans-2-(substituted amino)-cyclohehyl esters. Fine Chemical Technologies. 2007;2(6):85-89. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)