Preview

Fine Chemical Technologies

Advanced search

Investigation of synthesis of cytosine-containing monomer for negatively charged peptide nucleic acids.

Full Text:

Abstract

A cytosine-containing monomer for negatively charged peptide nucleic acids has been prepared for the first time, and the ways of its synthesis have been optimized.

About the Authors

A. V. Baranov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


N. S. Tsvid
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. I. Lukyanchenko
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. I. Prokhorov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


Yu. G. Kirillova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


V. I. Shvets
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. Sequence-selective recognition of DNA by strand displacement with a thyminesubstituted polyamide / P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchard // Science. – 1991. – № 254. – P. 1497 – 1500.

2. Синтез тиминсодержащего мономера отрицательно заряженных ПНК / Д. И. Прохоров, Н. П. Боярская, Ю. Г. Кириллова, А. Н. Тевяшова, О. В. Есипова, Е. Н. Звонкова, В. И. Швец // Хим.-фарм. журнал. – 2005. – Т. 39, № 6. – С. 3 – 43.

3. Synthesis of protected pseudopeptides from dicarboxylic amino acids by Mitsunobu condensation / N. P. Boyarskaya, D. I. Prokhorov, Yu. G. Kirillova, E. N. Zvonkova, V. I. Shvets // Tetrahedron Lett. – 2005. – Vol. 46, № 43. – P. 7359 – 7362.

4. Синтез двух новых тиминсодержащих мономеров отрицательно заряженных ПНК / Н. П. Боярская, Ю. Г. Кириллова, Д. И. Прохоров, Е. А. Стотланд, Е. Н. Звонкова, В. И. Швец //Доклады Академии наук. – 2006. – Т. 408, № 1. – С. 55 – 58.

5. Synthesis of peptide nucleic acid monomers containing the four natural nucleobases: thymine, cytosine, adenine, and guanine and their oligomerization / K. Dueholm [et al] // J. Org. Chem. – 1994. – Vol. 59, № 19. – P. 5767–5773.

6. Meltzer, P.C. Peptide nucleic acids: synthesis of thymine, adenine, guanine, and cytosine nucleobases / P.C. Meltzer, A.Y. Liang, P. Matsudaira // J. Org. Chem. – 1995. – Vol. 60, № 13. – P. 4305 – 4308.

7. General atomic and molecular electronic structure system / M.W. Schmidt [et al] // J. Comput. Chem. – 1993. – Vol. 14, № 11. – P. 1347 – 1363.

8. Freitag, M.A. Predicting shielding constants in solution using gauge invariant atomic orbital theory and the effective fragment potential method / M.A. Freitag [et al] // J. Chem. Phys. – 2004. – Vol. 120, № 3. – P. 1197 – 1202.


For citation:


Baranov A.V., Tsvid N.S., Lukyanchenko V.I., Prokhorov D.I., Kirillova Yu.G., Shvets V.I. Investigation of synthesis of cytosine-containing monomer for negatively charged peptide nucleic acids.. Fine Chemical Technologies. 2007;2(5):28-32. (In Russ.)

Views: 43


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)