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Synthesis of monomers of γ-polyamide nucleic acids mimics

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Abstract

Universal efficient preparative approach for obtaining of γ-substitued polyamide DNA-mimics on the base of L-alanine and L-glycine derivates was presented. As result of research cytosine and adenine-containing final monomers were synthesised. It was found that both allyl and methyl C-terminal protecting group can be used in the synthesis as example of cytosine-containing derivates.

About the Authors

A. V. Dezhenkov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


M. A. Lyanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. I. Prokhorov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


N. E. Lysenko
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


O. V. Esipova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


Yu. G. Kirillova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


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For citation:


Dezhenkov A.V., Lyanov M.A., Prokhorov D.I., Lysenko N.E., Esipova O.V., Kirillova Yu.G. Synthesis of monomers of γ-polyamide nucleic acids mimics. Fine Chemical Technologies. 2011;6(6):72-76. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)