Anatolii I. Miroshnikov, Doctor of Sciences (Chemistry), Academician, Member of the Presidium of the Russian Academy of Sciences (RAS), Chairman of the Presidium of the Pushchino Research Center of the Russian Academy of Sciences, Head of the Biotechnology Laboratory of the Russian Academy of Sciences Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov, Moscow, Russian Federation.
Hirsch-Index 18 (Scopus, December 2022)
Phone: +7 (495) 995-55-57#2005
Address: 16/10, Ulitsa Miklukho-Maklaya, GSP-7, Moscow, 117997, Russian Federation.
E-mail: aiv@ibch.ru
Academician Anatolii I. Miroshnikov is a prominent scholar in the fields of biotechnology, technology of natural and synthetic compounds, and bioorganic chemistry.
Academic Education and Career
Anatolii I. Miroshnikov graduated from the M.V. Lomonosov Moscow Institute of Fine Chemical Technology in 1963. In 1968, he was awarded the Candidate of Sciences degree for the dissertation titled “Mass spectrometric determination of the amino acid sequence in peptides containing residues of monoaminodicarboxylic acids and their ω-amides” at the Institute of Chemistry of Natural Compounds of the USSR Academy of Sciences. In 1989, he was awarded the Doctor of Chemistry degree for the dissertation titled “Structural and functional studies of polymyxin B, phospholipase A2, and apamine,” at NPO VILR of the Ministry of Medical and Microbiological Industry of the USSR.
Anatolii I. Miroshnikov previously worked at the Novosibirsk Institute of Organic Chemistry, Siberian Branch of the USSR Academy of Sciences as well as at the USSR Academy of Sciences Institute of Chemistry of Natural Compounds (today the Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences [IBCh RAS]). Between 1983 and 1986, he was Head of the Production Department of the USSR Ministry of Medical Industry. In years 1986–1987, he was the assistant to the Minister of Medical and Microbiological Industry of the USSR. Between 1987 and 1991, he held the role of the Director of the All-Union Scientific Research Institute of Medicinal Plants (VILR). In 1988, he became the General Director of the NPO VILR of the Ministry of Medical and Microbiological Industry of the USSR. Since 2004, he has been the acting Deputy Director of the IBCh RAS for scientific work (branch in Pushchino). Between 1991 and 2017, he was the Head of the Laboratory of Biotechnology at the same institution. Since 2017, he has been a research supervisor in the field of Bioengineering.
Anatolii I. Miroshnikov is an Academician, Member of the Presidium of the Russian Academy of Sciences (since 2008), Chairman of the Presidium of the Pushchino Research Center of the Russian Academy of Sciences (since 2006), and Head of the Biotechnology Laboratory of the Russian Academy of Sciences Institute of Bioorganic Chemistry named after Academicians M.M. Shemyakin and Yu.A. Ovchinnikov.
Research Interests
– Structural and functional studies of proteins and peptides with a gradual transition to the investigation of recombinant drugs important for modern biotechnology;
– Development and implementation of an integrated approach for investigating proteins and peptides by genetic and protein engineering methods. Creation of a technology for the production of Russian recombinant human insulin and recombinant peptide hormone, namely somatropin, in cooperation with the biocatalysis laboratory of IBCh RAS. The pilot production of drugs for these hormones has commenced and is functioning effectively. Based on the future needs, interferon α-2b, β-1b, and human granulocyte colony stimulating factor genes, were cloned, and the corresponding bacterial producer strains were developed;
– Development of technologies for the production of biologically active compounds of plant origin using plant cell cultures. In addition to recombinant proteins, technologies have been developed for the production of a cell wall disaccharide from Micrococcus lysodecticus and M. luteus, which is the main component of the Likopid immunostimulating drug as well as anticancer agents based on the modified nucleosides, namely Kladribin and Fludarabine. Technologies have been established for the production of modified nucleoside and nucleotide derivatives, including key antiviral and antitumor drugs, by chemoenzymatic methods.
Publications and Academic Advising
The results of the research conducted by Anatolii I. Miroshnikov have been published in over 200 scientific articles. In addition, 42 patents of the Russian Federation have been received. Anatolii I. Miroshnikov was a supervisor of 2 doctoral and 10 candidate dissertations.
He is member of the Editorial Boards of the Biotechnology journal, Questions of Biological, Medical and Pharmaceutical Chemistry journal, and Tonkie Khimicheskie Tekhnologii [Fine Chemical Technologies] journal. Anatolii I. Miroshnikov is the Vice President of the Russian Society of Biochemists and Molecular Biologists. He also holds the position of the Deputy Chairman of the Scientific Council of the Russian Academy of Sciences for Scientific Instrumentation. He is the Vice President of the All-Russian public organization Society of Biotechnologists of Russia named after Academician Yu.A. Ovchinnikov. He is a Member of RAS Coordination Board for Innovation and a Chairman of the Presidium of the Pushchino Scientific Center of the Russian Academy of Sciences. He is also a Member of the Presidium of the Russian Academy of Sciences.
Awards
– Medals “For Labor Valor” (1975 and 1981);
– Award of the Government of the Russian Federation in the field of science and technology for the development of a method for biotechnological production of lycopide, a new immunocorrective drug (1996);
– Anniversary medal “In memory of the 850th anniversary of Moscow” (1997);
– Order “For Merit to the Fatherland,” II degree, for important contribution to the development of Russian science and in connection with the 275th anniversary of the Russian Academy of Sciences (1999);
– Order of Friendship for the achievements in science and many years of successful research activity (2005);
– Award of the Government of the Russian Federation in the field of science and technology for the production and introduction of genetically engineered human insulin for application in the health care sector in Russia (2005).
