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Synthesis of diglycerides containing polyunsaturated fatty acids

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Abstract

Synthetic approaches to obtain diglycerides containing polyunsaturated fatty acids at C(2 ) position of glycerol were developed. These compounds can be used to generate antitumor lipids and enzymatically triggered liposomes .

About the Authors

M. S. Tsapleva
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


N. V. Plyavnik
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


G. A. Serebrennikova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. Li Z., Tranb V.H., Duked R.K., Yangc D., Duke C.C. Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids // Chem. Phys. Lipids. 2009. V. 158. P. 39–45.

2. Jaracz S., Chen J., Kuznetsova L.V., Ojima I. Recent advances in tumor-targeting anticancer drug conjugates // Bioorg. Med. Chem. 2005. V. 13. P. 5043–5054.

3. Johns B.A., Grant C.M., Marshall J.A. Synthesis and utilization of indium (I) iodide for in situ formation of enantioenriched allenylindium reagents and their addition to aldehydes: (2R,3S,4S)-1-(tert-Butildiphenylsylyloxy)-2,4-dimethyl-5-hexyn-3-ol // Org. Synth. 2004. V. 10. P. 170–178.

4. Dembinski R. Recent advances in the Mitsunobu reaction: Modified reagents and the quest for chromatography-free separation // Eur. J. Org. Chem. 2004. V. 13. P. 2763–2772.

5. Wipf P., Xu W. Allylic alcohols by alkene transfer from zirconium to zinc: 1-[(tert-butyl-diphenylsilyl)oxy]-dec-3-en-5-ol // Org. Synth. 1997. V. 74. P. 205

6. Плявник Н.В., Маслов М.А., Серебренникова Г.А. Синтез катионных глицеролипидов алкильного типа с функциональными группами в полярном домене // Биоорг. химия. 2004. Т. 30. № 5. С. 507–511.

7. Groza N.V., Ivanov I.V., Romanov S.G., Shevchenko V.P., Myasoedov N.F., Nigam S., Myagkova G.I. Synthesis of tritium labelled 3(R)-HETE and 3(R),18(R/S)-DiHETE through a common synthetic route // J. Label. Compd. Radiopharm. 2004. V. 47. P. 11–17.

8. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification // Canadian J. Biochem. Physiol. 1959. V. 37. № 8. P. 911–917.


For citation:


Tsapleva M.S., Plyavnik N.V., Serebrennikova G.A. Synthesis of diglycerides containing polyunsaturated fatty acids. Fine Chemical Technologies. 2012;7(6):27-31. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)