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Synthesis of substituted 2-(1,2,4- triazol-3-yl)benzimidazoles

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Abstract

A solution-phase synthesis for the preparation of substituted 2-(1,2,4-triazol-3- yl)benzimidazoles from triazole aldehydes and ortho-phenylenediamines has been developed for the purpose of producing diverse lead generation libraries.

About the Authors

N. V. Ivanova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


S. I. Sviridov
ООО «Кембридж»
Russian Federation


A. E. Stepanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. Naito Y., Akahoshi F., Takeda S. //J. med. chem. – 1996. – V.39. – P. 3019-3029.

2. Clercq E.D. //J. clin. virol. – 2004. – V. 30. – P. 115-133.

3. Collin X., Sauleau A. //Bioorg. med. chem. letters. – 2003 – V. 13. – P. 2601-2605.

4. Papakonstantinou-Garoufalias S., Pouli N., Marakos P. //Formac. – 2002. – V. 57. – P. 973-977.

5. Hester J.B., Rudzik A.D., Kamdar B.V. //J. med. chem. – 1971. – V 14. – P. 1078-1081.

6. Thompson S.K., Eppley A.M., Frazer J.S. //Bioorg. med. chem. Lett. – 1994. – V. 4. – P.2441-2446.

7. Duncia J.V., Santella J.B., Higley C.A., VanAtten M.K. //Bioorg. Med. Chem. Lett. –1998. – V. 8. – P. 775-780.

8. Ranft D., Lehwark-Yvetot G., Schaper K.J. //Pharmazine. – 2001. – V 56. – P. 226.

9. Thiel W. //Z. chem. – 1990. – V. 30. – P. 365-367.

10. Thiel W., Mayer R. //J. f. prackt. chemie. – 1989. –V. 331. – P. 243-262.

11. Верещагина, Н.Н., Мелкозерова, Г.С., Фролова, Н.Н. // Khim. farm. zh. – 1973. – V. 7. – P. 18-20.

12. Sawhney, S.N., Gupta A. //Indidan j. chem. – Sect. B. – 1991. – V. 30. – P. 407-412.

13. Beaulieu, P.L., Hache B. //Synthesis. – 2003. – P. 1683-1692.

14. Ivanova N.V., Sviridov S.I., Stepanov A.E. //Tetrahedron letters. – 2006. – V. 47. – P.8025-8027.

15. Ivanova N.V., Sviridov S.I., Shorshnev S.V., Stepanov A.E. //Synthesis. – 2006. – V 1. –P. 156-160.


Review

For citations:


Ivanova N.V., Sviridov S.I., Stepanov A.E. Synthesis of substituted 2-(1,2,4- triazol-3-yl)benzimidazoles. Fine Chemical Technologies. 2006;1(5):79-82. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)