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Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.

Abstract

Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.

About the Authors

N. P. Boyarskaya
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


Yu. G. Kirillova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. S. Esipov
МГУ им. М.В. Ломоносова
Russian Federation


V. I. Shvets
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

1. Sequence-selective recognition of DNA by strand displacement with a thyminesubstituted polyamide / P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt // Science. – 1991. – Vol. 254. – P. 1497–1500.

2. Solid-phase synthesis of peptide-nucleic acids / L. Christensen, R. Fitzpatrick, B. Gildea, K. H. Petersen, H. F. Hansen, M. Egholm, O. Buchardt, P. E. Nielsen, J. Coull, R. H. Berg // J. Peptide Science. – 1995. – Vol. 3. – P. 175–183.

3. Синтез тиминсодержащего мономера отрицательно заряженных ПНК / Д. И. Прохоров, Ю. Г. Кириллова, Н. П. Боярская, А. Н. Тевяшова, О. В. Есипова, Е. Н. Звонкова, В. И. Швец // Хим.-фарм. журнал. – 2005. – Т. 39, №. 6. – С. 39–43.

4. Synthesis of protected pseudopeptides from dicarboxylic amino acids by Mitsunobu condensation / N. P. Boyarskaya, D. I. Prokhorov, Yu. G. Kirillova, E. N. Zvonkova, V. I. Shvets // Tetrahedron Lett. – 2005. – Vol. 46, № 43. – P. 7359–7362.

5. Tam, J. P. Mechanism for the removal of benzyl protecting groups in synthetic peptides by trifluoromethansulfonic acid – trifluoroacetic acid – dimethyl sulfide / J. P. Tam, W. F. Heath, R. B. Merrifield // J. Am. Chem. Soc. – 1986. – Vol. 108. – P. 5242–5251.

6. Гершкович, А. А. Химический синтез пептидов / А. А. Гершкович, В. К. Кибирев – Киев: Наукова думка, 1992. – 360 с.


Review

For citations:


Boyarskaya N.P., Kirillova Yu.G., Esipov D.S., Shvets V.I. Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond. Fine Chemical Technologies. 2007;2(5):33-36. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)