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Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.

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Abstract

Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.

About the Authors

N. P. Boyarskaya
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


Yu. G. Kirillova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


D. S. Esipov
МГУ им. М.В. Ломоносова
Russian Federation


V. I. Shvets
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation


References

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For citation:


Boyarskaya N.P., Kirillova Yu.G., Esipov D.S., Shvets V.I. Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.. Fine Chemical Technologies. 2007;2(5):33-36. (In Russ.)

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ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)