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SCIENTIFIC SCHOOL OF ACADEMICIAN VITALY I. SHVETS: BIONANOPHARMACEUTICAL TECHNOLOGIES OF INNOVATIVE DIRECTED-ACTION MEDICINAL PREPARATIONS AND MANPOWER TRAINING

https://doi.org/10.32362/2410-6593-2017-12-6-5-31

Full Text:

Abstract

The results of many years of scientific research in the field of physico-chemical biology and its most important direction - lipidology, conducted by the leading scientific school under the leadership of Academician RAS Vitaly I. Shvets, are reported. On the creation of synthetic, biotechnological methods for obtaining lipids, with the possibility of their practical use by designing on this basis effective diagnostic and medicinal products and application in practical medicine. The further development and use of methods of bionanotechnology for the development of modern medicines for directed action on the basis of increasing the effectiveness of classical drugs by their incorporation into nanocontainers is described. It is reported on the development of technologies for obtaining nanoscale forms of drugs, the study of their pharmacological properties and use in medical practice. Information is provided on the preparation of liposomal antitumor, hepatoprotective, anti-tuberculosis, cardiac preparations based on the proposed echnologies, the study of properties and the use for therapeutic purposes. The technologies for obtaining and conducting biological studies of nanoforms based on copolymers of lactic and glycolic acids of antineoplastic, anti-inflammatory, antibacterial and a number of other drugs have been developed: It has been shown that the use of nanosized drugs can lead to a significant increase in the pharmacological effect due to various factors. It was noted that during the construction of the drug for the treatment of Parkinson's disease, the contents of liposomes loaded with dopamine pass through the blood-brain barrier almost 100 times better than individual dopamine molecules. Finding a substance in nanoparticles reduces its toxicity primarily due to the effect of "passive targeting". The prolonged action of medicinal substances enclosed in nanoparticles is discussed, due to their gradual release. It is noted that the targeted delivery of nanoparticles makes it possible to increase the effectiveness of the drugs by an order of magnitude. It is reported on the drug-delivery technology in the field of oncology and the use of the method of selective delivery of cytostatics to tumor tissues using the receptor-mediated endocytosis. Biological and pharmacological studies based on nanopoporous silicon on the creation of liposomal drugs for the treatment of cancer, cardiological pathologies, tuberculosis are carried out. Data on the work of the scientific and educational center for training specialists in the field of biotechnology and pharmacy are given.

About the Authors

V. I. Shvets
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Academician of the Russian Academy of Sciences, Professor, D.Sc. (Chemistry), Professor of the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo Pr., Moscow, 119571, Russia)



G. M. Sorokoumova
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Docent, Ph.D. (Chemistry), Associate Professor of the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo Pr., Moscow, 119571, Russia



A. I. Lyutik
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Ph.D. (Chemistry), Senior Researcher, the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo Pr., Moscow, 119571, Russia



A. B. Pshenichnikova
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Docent, Ph.D. (Chemistry), Associate Professor of the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo Pr., Moscow, 119571, Russia



D. I. Prokhorov
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Ph.D. (Chemistry), Senior Researcher, the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo Pr., Moscow, 119571, Russia



N. V. Rukosueva
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Assistant of the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo Pr., Moscow, 119571, Russia



A. G. Yakovenko
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Professor, D.Sc. (Engineering), Head of the Chair of Materials Science and Technology of Functional Materials and Structures

86, Vernadskogo Pr., Moscow, 119571, Russia



A. M. Khort
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Postgraduate Student of the Chair of Materials Science and Technology of Functional Materials and Structures

86, Vernadskogo Pr., Moscow, 119571, Russia



S. N. Chvalun
Moscow Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Professor, D.Sc. (Chemistry), Head of the S.S. Medvedev Chair of Chemistry and Technology of Macromolecular Compounds

86, Vernadskogo Pr., Moscow, 119571, Russia



Yu. M. Krasnopolsky
National Technical University «Kharkiv Polytechnic Institute
Ukraine

Professor, D.Sc. (Pharmacy), Professor of the Chair of Biotechnology, Biophysics and Analytical Chemistry

21, Frunze Str., Kharkov, 61002, Ukraine



V. Yu. Balabanyan
M.V. Lomonosov Moscow State University
Russian Federation

D.Sc. (Pharmacy), Associate Professor of the Chair of Pharmaceutical Chemistry, Pharmacognosy and the Organization of Pharmaceutical Affairs, Faculty of Fundamental Medicine

1, Bld. 3, Leninskie Gory, Moscow, 119991, Russia



E. S. Severin
OJSC «All-Russian Scientific Center for Molecular Diagnostics and Treatment»
Russian Federation

Corresponding Member of the Russian Academy of Sciences, Professor, D.Sc. (Chemistry), Scientific Director

8, Simferopolskiy Blvd., Moscow, 117638, Russia



A. A. Kubatiev
Research Institute of General Pathology and Pathophysiology RAS
Russian Federation

Academician of the Russian Academy of Sciences, Professor, D.Sc. (Medicine), Scientific Director of the Institute, Head of the Department of Molecular and Cell Pathophysiology, Research,

8, Baltiyskaya Str., Moscow, 125315, Russia



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78. Rukusueva N.V., Zakharova D.A., Bezrukov D.A., Kaplun A.P., Shvets V.I., Zigangirova N.A., Gintsburg A.A. Liposomal form of desferal as an effective antichlamydial agent // Vestnik MITHT (Fine Chemical Technologies). 2012. V. 7. № 6. P. 22–26. (in Russ.).

79. Prokhorov D.I., Antyasova M.N., Kapitsa I.G., Abaimov D.A., Seifulla R.D., Shvets V.I. Development and study of the properties of the emulsion form of an antiepileptic preparation // Biofarmatsevticheskiy zhurnal (Russ. Biopharm. J.). 2015. V. 7. № 2. P. 9–12. (in Russ.).

80. Malkovskaya G.M., Viktorov A.V., Vasilenko I.A., Mironov A.F., Shvets V.I., Evstigneeva R.P., Obraztsov V.V., Tarakhovsky Yu.S., Borovyagin V.L., Petrov V.I., Sennikov G.A. Effect of cytochrome C on the movement of phosphatides and permeability in model phospholipid membranes. Investigation by NMR method // Bioorganicheskaya khimiya (Russ. J. Bioorg. Chem.). 1982. V .8. P. 1563–1567. (in Russ.).

81. Balabanyan V.Yu., Ulyanov AM, Kapanadze G.D., Hamdi Ya.M., Shvets V.I. Antitumor activity of nanoscale form of paclitaxel in relation to the experimental form of mammary gland in C57-13216 mice // Biomeditsina (Biomedicine). 2014. № 4. P. 19–24. (in Russ.).

82. Maksimenko O.O., Vanchugova L.V., Shipulo E.V., Shandryuk G.A., Bondarenko G.N., Gelperina S.E., Shvets V.I. Influence of technological parameters on physicochemical properties of polylactide nanoparticles containing rifampicin // Khimiko-farmatsevticheskiy zhurnal (Chem.-Pharm. Zh). 2010. № 3. P. 42–47. (in Russ.).

83. Egorova-Zacherniuk T.A., Bosman V.I., De Green V.I., Shvets V.I. Introduction of a stable isotope label in the human histamine receptor HIR: a perspective for rational drug development // Doklady Akademii Nauk (Doklady Chemistry). 2010. V. 433. № 2. P. 257–261. (in Russ.).

84. Sevastyanov Yu.S., Rybakov Yu.L. Analytical and statistical data of the competitions of the FCTS in 2005-2006. On the priority direction «Living systems: Results of the open contest of the Federal Scientific Center for Scientific Research in the field of scientific schools in 2006» // FGU NII RINKTSE «Innovatika i ekspertiza». Nauchnyye trudy (FSUE RIINCE Research Institute «Innovation and Expertise»). Proceed.: Moscow, 2007. P. 112–122. (in Russ.).

85. Khalansky A.S., Hekmatarah T., Bernroyter K., Rubtsov B.V., Kondakova L.I., Matchka K., Kreuter I., Glatzel M., Helperina S.E., Shvets V.I. Morphological evaluation of the antitumor effect of the nanosomal form of doxorubicin against experimental glioblastoma in rats // Biofarmatsevticheskiy zurnal (Russ. Biopharm. J.). 2011. V. 3. № 2. P. 41–50. (in Russ.).

86. Tsalman A.Ya., Bezrukov D.A., Kaplun A.P., Poruchikova L.A., Shvets V.I. A method for determining the optimum composition of a mixture for the preparation of aqueous dispersions of spherical nanoparticles: pat. Ros. Federatsiya (Patent RF). 2424516. 2011. (in Russ.).

87. Kaplun A.P., Bezrukov D.A., Shvets V.I. Rational design of nano- and micron-size medicinal forms of biologically active substances // Biotekhnologiya (Biotechnology). 2010. № 6. P. 9–18. (in Russ.).

88. Kaplun A.P., Bezrukov D.A., Popenko V.I., Shvets V.I. Spherical amorphous nanoparticles from birch bark triterpenoides - a new type of submicron drug delivery devices // Biofarmatsevticheskiy zurnal (Russ. Biopharm. J.). 2011. V. 3. № 2. P. 19–28. (in Russ.).

89. Nguyen H.K., Chupin V.V., Prokhorov D.I., Chikunov I.E., Kovtun V.Yu., Tarumov R.A., Grebenyuk A.N., Shvets V.I. Creation and study of nanoparticles based on a mixture of birch bark triterpenoids and genistein radio-protective substance //Doklady Akademii Nauk (Doklady Chemistry). 2015.

90. V. 464. № 6. P. 750–754. (in Russ.).

91. Kaplun A.P., Bezrukov D.A., Rodina A.V., Popenko V.I., Shvets V.I. Modern nanomedicine // Nanomeditsina. Spetsialnyy vypusk zhurnala «Nanotekhnika». 2007. Prilozhenyek № 9 (Nanomedicine. Special issue of the journal "Nanotechnique". 2007. Supplement to №. 9). P. 132–145. (in Russ.).

92. Severin E.S. New approaches to the selective delivery of drugs to tumor cells // Uspekhi Khimii (Russian Chemical Reviews). 2015. V. 84. № 1. P. 43–60. (in Russ.).

93. Nikolskaya E.D., Zhunina V.A., Yabbarov N.G., Shvets V.I., Krugly B.I., Severin E.S. Development of target delivery systems of antitumor drugs of actinomycin series by recombinant α-fetoprotein // Doklady Akademii Nauk (Doklady Chemistry). 2017. V. 473. № 6. P. 739–741. (in Russ.).

94. Nikolskaya E.D., Zhunina O.A., Yabbarov N.G., Shvets V.I., Krugliy B.I., Severin E.S. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. V. 473. P. 148–150.

95. Egorova E.V., Kubatiev A.A., Schvets V.I. Biological Effects of Metal Nanoparticles. Moscow: Nauka Publ., 2014. 350 p. (in Russ.).

96. Egorova E.V., Kubatiev A.A., Schvets V.I. Biological Effects of Metal Nanoparticles. Switzerland: Springer Int. Publ., 2016. 292 p.

97. Andreevskaya S.N., Smirnova T.G., Zhogina Yu.A., Smirnova D.I., Mikulovich Yu.L., Sorokoumova G.M., Chernousova L.N., Selischeva A.A., Shvets V.I. The effect of exogenous cardiolipin on the growth and viability of the culture of Mycobacterium tuberculosis H37RV in vitro // Doklady Akademii Nauk (Doklady Chemistry) 2010. V. 434. № 5. P. 705–708. (in Russ.).

98. Smirnova T.G., Mikulovich Yu.L., Andreevskaya S.N., Sorokoumova G.M., Chernousova L.N., Selischeva A.A., Shvets V.I. Lysoproducts of cardiolipin suppress the viability of sensitive and resistant strains of Mycobacterium tuberculosis // Biofarmatsevticheskiy zurnal (Russ. Biopharm. J.). 2011. V. 3. № 2. P. 19–27. (in Russ.).

99. Krasilnikov I.V., Gambaryan A.S., Mashin V.V., Lobastova A.K. Immunogenic and protective properties of inactivated and live vaccine candidates against highly pathogenic H5N1 viruses // Voprosy virusologii (Problems of Virology). 2010. № 4. P. 21–24. (in Russ.).

100. Abramova E.N., Khort A.M., Yakovenko A.G., Prokhorov D.I., Syrov Y.V., Shvets V.I. About the formation of pores n-Si during its electrochemical etching // Proceed. XI Int. Academic Congress «Contemporary Science and Education in Americas, Africa and Eurasia». Brazil, Rio de Janeiro, 19-21 November 2016. UFRJ Press. 2017. P. 152–154.

101. Abramova E.N., Khort A.M., Syrov Y.V., Yakovenko A.G., Shvets V.I. The effect of the hydrofluoric acid – silicon system anisotropy on the shape of pores formed upon electrochemical etching of silicon // Doklady Akademii Nauk (Doklady Chemistry). 2015. V. 464. № 1. P. 224–226.

102. Abramova E.N., Khort A.M., Yakovenko A.G., Shvets V.I. Control of dimension of nanopores and structure of layers of nanoporous silicon during its electrolytic etching in hydrofluoric acid solutions // Doklady Akademii Nauk (Doklady Chemistry). 2015. V. 462. № 1. P. 109–111.

103. Abramova E.N., Khort A.M., Yakovenko A.G. Shvets V.I. Nanopore formation during electrolytic etching of silicon in hydrofluoric acid solutions // Neorganicheskie materialy (Inorganic Materials). 2015. V. 51. № 8. P. 747–753.

104. Abramova E.N., Khort A.M., Tsygankov V.N., Yakovenko A.G., Shvets V.I. The Role of etchant ion in the formation and growth of pores in silicon during its etching in hydrofluoric acid solutions // Doklady Akademii Nauk (Doklady Chemistry). 2016. V. 467. № 1. P. 61–63.

105. Abramova E.N., Khort A.M., Yakovenko A.G., Prokhorov D.I., Shvets V.I. Pore nucleation and growth in n-type Si during its electrochemical etching // Doklady Akademii Nauk (Doklady Chemistry). 2017. V. 473. № 2. P. 67–69.

106. Shobolov D.A., Krasnopolsky Yu.M., Ulyanov A.I, Natykan A.A., Tarasov V.V., Balabanyan V.Yu., Shvets V.I, Stadnichenko A.V. Method for obtaining the liposomal form of irinotecan. Pat. 023079. Eurasian patent № 201201590, filed. 24.12.2012, publ. 04.29.2016. (in Russ.).

107. Shobolov D.A., Krasnopolsky Yu.M., Ulyanov A.I., Natiqan A.A., Tarasov V.V., Balabanyan V.Yu., Shvets V.I. Method for obtaining liposomal form of oxaliplatin. Pat. 023757. Eurasian patent № 201201596, filed. 24. 12.2012, publ. 07.09.2016. (in Russ.).

108. Shobolov D.A., Krasnopolsky Yu.M., Ulyanov A.I., Natykan A.A., Tarasov V.V., Balabanyan V.Yu., Shvets V.I., Prokhorov V.V. Method for obtaining the liposomal form of docetaxel. Pat. 022182. Eurasian patent № 201201592, filed. 24.12.2012, publ. 11.30.2015. (in Russ.).

109. Shobolov D.A., Krasnopolsky Yu.M., Ulyanov A.I., Natykan A.A., Tarasov V.V., Balabanyan V.Yu., Shvets V.I., Katsai A.G. Method for obtaining the liposomal form of cytochrome C. Pat. 022183. Eurasian patent № 201201591, filed 24.12.2012, publ. 11.30.2015. (in Russ.).

110. Shobolov D.A., Krasnopolsky Yu.M., Ulyanov A.I., Natykan A.A., Tarasov V.V., Balabanyan V.Yu., Shvets V.I. Method for obtaining the liposomal form of quercetin. Pat. 021352. Eurasian patent № 201201593, filed. 24.12.2012, publ. 05.29.2015. (in Russ.).

111. Shobolov D.A., Krasnopolsky Yu.M., Ulyanov A.I., Natiqan A.A., Tarasov V.V., Balabanyan V.Yu., Shvets V.I. Method for the preparation of an inhaled liposomal form of rifabutin. Pat. 023080. Eurasian patent № 201201595, filed. 24.12.2012, publ. 29.04.2016. (in Russ.).

112. Krasnopolskii Yu.M., Grigor’eva A.S., Katsai A.G., Konakhovich N.F., Prokhorov V.V., Stadnichenko A.V., Balaban’yan V.Yu., Lyutik A.I., Shvets V.I. Technologies and perspectives for the use of liposomal drug application in clinical practice // Nanotekhnologii v Rossii (Nanotechnologies in Russia). 2017. V. 12. № 7-8. P. 449–458.

113. Rukosueva N.V., Bezrukov D.A., Kaplun A.P., Shvets V.I. Preparations on the basis of anoparticles in clinical practice: achievements and prospects // Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii (Questions Problems of Biol. Med. Pharm Chem.). 2014. V. 12. № 10. P. 3–22. (in Russ.).

114. Shakhmayev A.E., Katsai A.G., Prokhorov V.V., Stadnichenko A.V., Balabanyan V.Yu., Krasnopolsky Yu.M., Shvets V.I. Investigation of the methods of inclusion of medicinal substances in liposomal nanoparticles // Remedium (Remedium). 2015. № 312. P. 56–59. (in Russ.).

115. Krasnopolsky Yu.M., Balabanyan V.Yu., Shobolov D.L., Shvets V.I. Prospects of application of nanosized forms of medicinal products in clinical practice // Rossiiskii Khimicheskii Zhurnal (Russian Journal of Chemistry). 2012. V. 56. № 3-4. C. 11–32. (in Russ.).

116. Shvets V.I., KubatievA.A., Shobolov D.L., Balaban’yan V.Yu. Biopharmaceutical Technologies Based on Phospholipids (Chemistry, Biochemistry, Biophysics, Biotechnology, Physiology, Immunology, Pharmacology, and Production Technologies of Medicinal and Diagnostic Preparations, Including Nanosized Preparations) // Review Journal of Chemistry. 2013. V. 3. № 3. P. 179–206.

117. Pattni B.S., Chupin V.V., Torchilin V.P. New developments in liposomal drug delivery // Chem. Rev. 2015. V. 115. № 19. P. 10938–10966.

118. Oltarzhevskaya N.D., Shvets V.I., Korovina M.A., Lipatova I.M., Khlystova Т.S. The choice of the composition of the biopolymer therapeutic depot composition for use in various fields of medicine // Biotekhnologiya (Biotechnology). 2016. № 1. P. 43–52. (in Russ.).

119. Shvets V.I. Biopharmaceutical technologies for creating medicines (science, pharmacology, education) // Jubilee scientific readings dedicated to the 120th anniversary of Prof. N.A. Preobrazhensky. 20.10.2016. Moscow: Genesis Publ., 2016. P. 214-223. (in Russ.).

120. Pshenichnikova A.B., Shvets V.I. Training of personnel in the department of biotechnology and bionanotechnology at the MITHT named by M.V. Lomonosov // Vestnik MITHT (Fine Chemical Technologies). 2011. V. 6. № 2. P. 8–14. (in Russ.).

121. Lisitsa A.V., Kornushko V.F., Shvets V.I. The principle of «desk research» in the sciences of life // Integral (Integral). 2012. № 3. P. 14–15. (in Russ.).

122. Pshenichnikova A.B., Bragina N.A., Solomonov V.A., Biglov R.R., Shvets V.I. Directions for the training of highly qualified personnel for the innovative biopharmaceutical industry at the MITHT named by M.V.Lomonosov // Proceed. of VIII Moscow Int. Congress «Biotechnology: state and development prospects». Russia, Moscow, 17–20 March 2015. P. 427–428. (in Russ.).

123. Nosov G.A., Zinovkina T.V., Odintsov K.Yu., Pobedimsky D.G., Shvets V.I. Engineering bases of biotechnology. / Ed. by V.I. Shvets. 1st Ed. Moscow: MITHT, 1998. 386 p. 2nd Ed. Moscow: MITHT, 2004. 379 p. (in Russ.).

124. Bragina N.A., Pshenichnikova A.B., Biglov R.R., Shvets V.I. Development and implementation of educational programs within the system of continuous training of biotechnological personnel for biopharmaceuticals // Aktual'naya biotekhnologiya (Actual Biotechnology) Actual Biotechnology. 2014. № 3. P. 25–26. (in Russ.).

125. Biglov R.R., Kornushko V.F., Ovchinnikova T.V., Shvets V.I. Innovative educational cluster of training specialists in biotechnology. Proceed. of the1st Int. Scientific and Practical Conference «Chemistry, bio and nanotechnologies, ecology and economics in the food and cosmetic industry». Ukraine, Crimea, Schelkino, 10–13 June, 2013. P. 270–271. (in Russ.).

126. Biglov R.R., Bragina N.A., Pshenichnikova A.B., Shvets V.I. Development of educational programs for the development of the pharmaceutical industry «Biotechnology». Proceed. of the 1st Int. Scientific and Practical Conference «Chemistry, bio and nanotechnologies, ecology and economics in the food and cosmetic industry». Ukraine, Crimea, Schelkino, 10–13 June 2013. P. 270–271. (in Russ.).

127. Shvets V.I., Pshenichnikova A.B., Bragina N.A., Biglov R.R. Creation of a system of continuous training of biotechnological personnel for the domestic pharmaceutical industry. Proceed. of the IV Int. Symposium «Biopharma-2013: from science to industry». Montenegro, Budva, 9–14 September 2013. P. 31. (in Russ.).

128. Pshenichnikova A.B., Shvets V.I. Strategy of training specialists for the biopharmaceutical industry. Proceed. of St. Petersburg Int. Forum on Pharmaceutics and Biotechnology. St. Petersburg, 26-28 April 2011. P. 169–170. (in Russ.).

129. Pshenichnikova A.B., Bragina N.A., Biglov R.R., Shvets V.I. Innovative scientific and educational complex «Personnel for biotechnology (biopharmaceutical technology)». Proceed. of St. Petersburg Int. Forum «Pharmaceutics. Medicinal industry. Biotechnology». St. Petersburg. 2012. P.164–165. (in Russ.).

130. Shvets V.I., Pshenichnikova A.B., Bragina N.A., Biglov R.R. Organization of continuous training of personnel in biotechnology for the pharmaceutical industry within the framework of the FTP «PHARMA 2020». Proceed. of the Int. Scientific Conference «Achievements and prospects for the development of biotechnology». Saransk, 3-5 October 2012. P. 158–159. (in Russ.).

131. Pshenichnikova A.B., Sorokoumova G.M., Bragina N.A., Kirillova Yu.G., Shvets V.I. Modern scientific and methodological basis of modernization of the system of domestic biotechnological education in the field of biopharmaceutical technologies (university and postgraduate education). Proceed. of the Int. Scientific and Practical Conference «Pharmaceutical and Medical Biotechnologies». Russia, Moscow, 20-22 March 2012. Р. 131–132. (in Russ.).

132. Shvets V.I., Biglov R.R. Exemplary basic educational programs for undergraduate and graduate programs in the field of «Biotechnology». Proceed. of the Int. Congress «Biotechnology: state and development prospects». Russia, Moscow, 20-22 February 2017. Р. 511–512. (in Russ.).

133. Shvets V.I., Biglov R.R. On the training of personnel in the field of biotechnology // Vestnik vysshej shkoly. Praktika vysshej shkoly (Bulletin of the Higher School. The Practice of Higher Education). 2017. № 6. P. 71–76. (in Russ.).


For citation:


Shvets V.I., Sorokoumova G.M., Lyutik A.I., Pshenichnikova A.B., Prokhorov D.I., Rukosueva N.V., Yakovenko A.G., Khort A.M., Chvalun S.N., Krasnopolsky Yu.M., Balabanyan V.Yu., Severin E.S., Kubatiev A.A. SCIENTIFIC SCHOOL OF ACADEMICIAN VITALY I. SHVETS: BIONANOPHARMACEUTICAL TECHNOLOGIES OF INNOVATIVE DIRECTED-ACTION MEDICINAL PREPARATIONS AND MANPOWER TRAINING. Fine Chemical Technologies. 2017;12(6):5-31. (In Russ.) https://doi.org/10.32362/2410-6593-2017-12-6-5-31

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