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CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS

https://doi.org/10.32362/2410-6593-2016-11-6-68-74

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Abstract

The changes of the 8-oxo-2'-deoxyguanosine (8-oxo-dG)/dG ratio in the DNA of laboratory mice hepatocytes under the influence of toxic stress were studied. It was shown that the injection of carbon tetrachloride causes the growth of 8-oxo-dG level. A rapid increase in the level of 8-oxo-dG in DNA occurs during the first day of the experiment at short-term toxic stress. Subsequently, 48 hours after the initial injection, the level of 8-oxo-dG decreases to the control values. This change in the value of the biomarker can be attributed to the activation of the reparative and antioxidant systems. The subsequent injection results again in an increase of 8-oxo-dG level, and the latter only increases thereafter. This reflects the exhaustion of the reparative potential of the organism and accompanies the progress of inflammation and pathological change of the liver tissue.

About the Authors

N. V. Marmiy
Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Moscow, 119991 Russia


D. S. Esipov
Faculty of Biology, Lomonosov Moscow State University
Russian Federation
Moscow, 119991 Russia


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For citation:


Marmiy N.V., Esipov D.S. CHANGES OF 8-OXO-2'-DEOXYGUANOSINE LEVEL IN MOUSE LIVER CELLS DNA IN CASE OF ACUTE TOXIC STRESS. Fine Chemical Technologies. 2016;11(6):68-74. https://doi.org/10.32362/2410-6593-2016-11-6-68-74

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