Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives

Objectives. To synthesize derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes and evaluate their effect on platelet aggregation and plasma hemostasis.

Methods. To determine the qualitative and quantitative composition of the reaction masses, gas chromatography-, chromate mass spectrometry-, and ¹H and ¹³C nuclear magnetic resonance spectrometry methods were used.

Results. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were obtained under thermal heating conditions in order to evaluate their effect on platelet aggregation and plasma hemostasis.

Conclusions. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were synthesized in high yields. Their effect on platelet aggregation and plasma hemostasis was established.

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