Preview

Fine Chemical Technologies

Advanced search

DEVELOPMENT OF REACTION-RECTIFICATION PROCESS OF OBTAINING MESITYL OXIDE. I. SIMULATION OF KINETICS AND PHASE EQUILIBRIUM IN THE REACTION SYSTEM

https://doi.org/10.32362/2410-6593-2018-13-5-5-13

Full Text:

Abstract

Mesityl oxide is an important product of organic synthesis, which is used in the manufacture of pharmaceuticals and as a solvent. The demand for mesityl oxide is growing, which determines the need for further improvement of its production. The disadvantages of the traditional methods of obtaining mesityl oxide are low values of reagent conversion and selectivity. To eliminate them, it is proposed to obtain mesityl oxide in a combined reaction-rectification process. The combination of chemical transformation and separation of the resulting reaction mixture by means of rectification in one apparatus allows for a continuous withdrawal of the formed products from the reaction zone, which increases the rate of the target reaction, conversion and selectivity. In accordance with the modern strategy for the development of chemical-technological processes, the collection and processing of physical and chemical information on the properties of the components and mixtures contained in the reaction system was performed. Based on the experimental data, the parameters of the phase equilibrium model are determined, and its adequacy is estimated. The phase equilibrium model was used to construct a distillation diagram, to verify its consistency, and to conduct computational studies of the reaction-rectification process. The thermochemical parameters of the target reactions are calculated, the equilibrium constants are determined, and their temperature dependence is established. On the basis of the analysis of the literature data, a kinetic model of the process is proposed, and the conditions favorable for the course of the desired chemical transformation are determined with the use of this model. The obtained data are necessary for carrying out the analysis of the statics, constructing the basic technological scheme and calculating its static parameters.

About the Authors

M. A. Yakhyaev
MIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Postgraduate Student, the Chair of Chemistry and Technology of Basic Organic Synthesis,

86, Vernadskogo Pr., Moscow 119571, Russia



V. S. Gutenkov
MIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Master Student, Chair of Chemistry and Technology of Basic Organic Synthesis

86, Vernadskogo Pr., Moscow 119571, Russia



Yu. A. Pisarenko
MIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

D.Sc. (Engineering), Professor of Chair of Chemistry and Technology of Basic Organic Synthesis

86, Vernadskogo Pr., Moscow 119571, Russia



References

1. Saayman N., Lund G.J., Kindermans S. Process for production of MIBK using CD technology: pat. US 6,762,328 B2 USA. No. 10/289,693; filed 11/07/2002; publ. 04/03/2003.

2. O’Keefe W.K., Jiang M., Ng F.T.T., Rempel G.L. Liquid phase kinetics for the selective hydrogenation of mesityl oxide to methyl isobutyl ketone in acetone over a Pd/Al2O3 catalyst. Chem.Eng. Sci. 2005; 60(15): 4131-4140.

3. Christopher R.H., Zheng S., Shylesh S., Bell A.T. The mechanism and kinetics of methyl isobutyl ketone synthesis from acetone over ion-exchanged hydroxyapatite. J. Catal. 2018; 365: 174-183.

4. Xu L., Wang F., Huang J., Yang Ch., Yu L., Fan Y. L-Proline and thiourea co-catalyzed condensation of acetone. Tetrahedron. 2016; 72(27-28): 4076-4080.

5. Yakhyaev M.A., Pisarenko Yu.A., Serna-Loaiza S., Kardona K.A. Analysis of stoichiometric patterns that limit the stationary state of the reaction-distillation processes. Tonkie khimicheskie tekhnologii (Fine Chemical Technologies). 2018; 8(1): 66-74. (in Russ.)

6. Losev Yu.P., Loseva L.P., Paushkin Ya.M., Isakovich V.N. A method for the joint preparation of mesityl oxide and acetone: pat. 734183 USSR. No. 2563375/23–04; filed 12/30/77; publ. 05/15/80. Bull. No. 18. (in Russ.)

7. Chernykh S.P., Timofeev V.S., Grigoryev A.A., Guseva S.I., Chebotaev V.F., Dolgij I.E., Pinkhasik E.V., Zavorotov V.I., Zil’ T.I., Katsman E.A., Asilova N.Yu. Method for producing mesityl oxide: pat. SU 1555322. No. 4275658/23-04; filed 07/01/87; publ. 04/07/90. (in Russ.)

8. Verkhovskaya Z.N., Klimenko M.Ya., Zalesskaya E.M., Bychkova I.N. Synthesis of diacetone alcohol and mesityl oxide on ion-exchange resins. Khimicheskaya promyshlennost’ (Chemical Industry). 1967; (7): 20-23. (in Russ.)

9. Keil F.J. Modeling of Process Intensification. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2007. 422 p.

10. Harmsen J. Reactive distillation: The frontrunner of industrial process intensification. A full review of commercial applications, research, scale-up, design and operation . Chem. Eng. & Proc. 2007; 7(46): 774-780.

11. Gorban A.N., Yablonskii G.S., Bykov V.I. The path to equilibrium. Int. Chem. Eng. 1982; 22(2): 368-375.

12. Pisarenko Yu.A., Serafimov L.A. To the statics of systems with chemical transformations. Teoreticheskie osnovy khimicheskoy tekhnologii (Theoretical Foundations of Chemical Technology). 1991; 25(5): 627-637. (in Russ.)

13. Rameshwar H.S., Nitin V.B., Yogesh M.S., Sanjay M.M. Industrial applications of reactive distillation: Recent trends. Int. J. Chem. Reactor Eng. 2004; 52(2): 1-52.

14. Pisarenko Yu.A., Serafimov L.A., Kulov N.N. The fundamentals of the analysis of the statics of reactionrectification processes with several chemical reactions. Teoreticheskie osnovy khimicheskoy tekhnologii (Theoretical Foundations of Chemical Technology). 2009; 43(5): 1-18. (in Russ.)

15. Kogan V.B., Fridman V.M., Kafarov V.V. Handbook of Solubility. Moscow: Akademiya nauk SSSR (Academy of Sciences of the USSR), 1961. V. 1. 970 p. (in Russ.)

16. Ogorodnikov S.K., Lesteva T.M., Kogan V.B. Azeotropic mixtures. Handbook. Leningrad: Khimiya Publ., 1971. 848 p. (in Russ.)

17. Zharov V.T., Serafimov L.A. Physicochemical basis of distillation and rectification. Leningrad: Khimiya Publ., 1975. 238 p. (in Russ.)

18. Thotla S., Agarwal V., Mahajani S.M. Simultaneous production of diacetone alcohol and mesityl oxide from acetone using reactive distillation. Chem. Eng. Sci. 2007; 8(62): 5567-5574.


For citation:


Yakhyaev M.A., Gutenkov V.S., Pisarenko Yu.A. DEVELOPMENT OF REACTION-RECTIFICATION PROCESS OF OBTAINING MESITYL OXIDE. I. SIMULATION OF KINETICS AND PHASE EQUILIBRIUM IN THE REACTION SYSTEM. Fine Chemical Technologies. 2018;13(5):5-13. (In Russ.) https://doi.org/10.32362/2410-6593-2018-13-5-5-13

Views: 183


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)