Preview

Fine Chemical Technologies

Advanced search

On the use of aqueous solutions of polyvinyl methyl ether for the embolization of blood vessels

https://doi.org/10.32362/2410-6593-2019-14-4-33-38

Full Text:

Abstract

Aqueous solutions of polyvinyl methyl ether were investigated in order to test whether it is possible to utilize them as bases for embolic agents used to deliberately block blood vessels. This may be necessary in the course of treatment of vascular abnormalities, tumors, as well as during the preparation of patients for surgery. The right branch of the binodal curve for the binary system “polyvinyl methyl ether–water” was drawn using the cloud point method and the lower critical mixing temperature (35.5 °C) was calculated. Furthermore, the exact concentration of polyvinyl methyl ether in aqueous solutions at which phase transition occurs (given the temperature of 35.5 °C) was found to be 30 wt %. The viscosity–velocity curves for the 30% solution of polyvinyl methyl ether, obtained by rheoviscometry in the temperature range of 5 to 36 °C, indicate that this aqueous solution has a low viscosity and behaves like a Newtonian fluid. However, at the temperature of 35 °C and higher, close to the phase transition, a significant deviation from its Newtonian behavior is observed due to precipitation of polyvinyl methyl ether as it forms a solid white mass. Through the use of the Arrhenius–Frenkel–Eyring equation, the activation energy of the viscous flow for polyvinyl methyl ether solutions was found to be 31 kJ/mol. Based on refractometry data, it was demonstrated that phase transition in aqueous solutions of polyvinyl methyl ether is reversible. This feature can facilitate medical equipment cleaning before introducing the embolic agent into a patient’s bloodstream. Finally, the investigation determined some parameters, in which the formation of embolic agents from a 30% polyvinyl methyl ether aqueous solution occurs (in situ in a blood vessel at a temperature of 35.5 °C).

About the Authors

P. E. Ignatieva
MIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Student of the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo pr., Moscow 119571, Russia



E. S. Zhavoronok
MIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Cand. of Sci. (Chemistry), Associate Professor, Chair of Biotechnology and Industrial Pharmacy

Scopus Author ID 7801409746,

ResearcherID H-9420-2013

86, Vernadskogo pr., Moscow 119571, Russia



O. A. Legonkova
A.V. Vishnevsky National Medical Research Center of Surgery, Ministry of Health of the Russian Federation
Russian Federation

Dr. of Sci. (Engineering), Head of the Department of Dressings, Suture and Polymeric Materials in Surgery

Scopus Author ID 18437207900

27, Bolshaya Serpukhovskaya ul., Moscow 117997, Russia



S. A. Kedik
MIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)
Russian Federation

Dr. of Sci. (Engineering), Professor, Head of the Chair of Biotechnology and Industrial Pharmacy

86, Vernadskogo pr., Moscow 119571, Russia



References

1. Kiron Varghese, Srilakshmi Adhyapak. Therapeutic Embolization. Bangalore, 2017. 133 p.

2. Chabrot P., Boyer L. Embolization. Springer, 2013. 472 p.

3. Dan V.N., Sapelkin S.V. Angiodysplasia (congenital vascular malformations). Moscow: Verdun Publ., 2008. 200 p.

4. Dan V.N., Sapelkin S.V., Legonkova O.A., Tsygankov V.N., Varava A.B., Kedik S.A., Lark E.S., Panov A.V. Materials and methods of endovascular treatment of arteriovenous malformations: Opportunities and Challenges. Voprosy biologicheskoi, meditsinskoi i farmatsevticheskoi khimii. Meditsinskaya khimiya [Issues of Biological, Medicinal and Pharmaceutical Chemistry. Medicinal Chemistry]. 2016;(7):49-51 (in Russ.).

5. Kedik S.A., Suslov V.V., Malkov A.P., Shnyak E.A., Domnina Yu.M. Gelling polymers to create a liquid embolic agents. Razrabotka i registratsiya lekarstvennykh sredstv [Development and Registration of Medicines]. 2017;4(21):38-45 (in Russ.).

6. Ignatieva P.E., Zhavoronok E.S., Legonkova O.A., Kedik S.A. Compositions based on aqueous solutions of chitosan and glutaraldehyde for embolization of blood vessels. Tonkie khimicheskie tekhnologii = Fine Chemical Technologies. 2019;14(1):14-20 (in Russ.). https://doi.org/10.32362/2410-6593-2019-14-1-25-31

7. Lu X.-Y., Zhang X. Onyx embolization for an angiographically progressive traumatic pseudoaneurysm of the middle meningeal artery: A case report and literature review. Exp. Ther. Med. 2019;17(5):4144-4148. https://doi.org/10.3892/etm.2019.7403

8. Vaidya S., Tozer K.R., Chen J. An overview of embolic agents. Semin. Intervent. Radiol. 2008;(25):204-215. https://doi.org/10.1055/s-0028-1085930

9. Jones J.P., Sima M., O'Hara R.G., Stewart R.J. Water-borne endovascular embolics inspired by the undersea adhesive of marine sandcastle worms. Adv. Healthc. Mater. 2018;5(7):795-801. https://doi.org/10.1002/adhm.201500825

10. Casalini R., Roland C.M. Dynamic properties of polyvinylmethylether near the glass transition. J. Chem. Phys. 2003;119(7):4052-4059.

11. PVME poly(vinyl methyl ether). In: Wypych G. Handbook of Polymers. Chem Tec Publishing, 2016. P. 646-648. https://doi.org/10.1016/C2015-0-01462-9

12.


Supplementary files

1. Fig. 2. A typical view of the PVME–water system, below (a) and above (b) the binodal curve
Subject
Type Исследовательские инструменты
View (121KB)    
Indexing metadata

For citation:


Ignatieva P.E., Zhavoronok E.S., Legonkova O.A., Kedik S.A. On the use of aqueous solutions of polyvinyl methyl ether for the embolization of blood vessels. Fine Chemical Technologies. 2019;14(4):33-38. https://doi.org/10.32362/2410-6593-2019-14-4-33-38

Views: 161


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)