chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).10.32362/2410-6593-2017-12-3-5-20chemicallytech-88Research ArticleCHEMISTRY AND TECHNOLOGY OF ORGANIC SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ОРГАНИЧЕСКИХ ВЕЩЕСТВTHE DETERMINATION OF PHENOLS COMPOUNDS IN DISINFECTANTSОПРЕДЕЛЕНИЕ ФЕНОЛЬНЫХ СОЕДИНЕНИЙ В ДЕЗИНФЕКЦИОННЫХ СРЕДСТВАХНосиковаА. А.NosikovaL. A.

кандидат химических наук, доцент кафедры химии и технологии редких и рассеянных элементов, наноразмерных и композиционных материалов им. К.А. Большакова И

119571, Россия, Москва, пр-т Вернадского, д. 86

Moscow 119571, Russia

noemail@neicon.ruМельниковИ. О.MelnikovI. O.

кандидат химических наук, заведующий сектором прикладной экологии воды

119991, Россия, Ленинский пр-т, д. 31

Moscow 119991, Russia

noemail@neicon.ruКочетовА. Н.KochetovA. N.

кандидат химических наук, химик-аналитик испытательной аналитической лаборатории А

143900, Россия, Московая область, Балашиха, ул. Парковая, д. 3

Balashikha, Moscow region 143900, Russia

kochchem@mail.ruМосковский технологический университет (Институт тонких химических технологий)РоссияMoscow Technological University (Institute of Fine Chemical Technologies)Russian FederationИнститут общей и неорганической химии им. Н.С. Курнакова РАНРоссияKurnakov Institute of General and Inorganic Chemistry, Russian Academy of SciencesRussian FederationАО «БВТ БАРЬЕР РУС»РоссияJSC «BVT BARIER RUS»Russian Federation201728062017123520Copyright © Nosikova L.A., Melnikov I.O., Kochetov A.N., 20172017Носикова А.А., Мельников И.О., Кочетов А.Н.Nosikova L.A., Melnikov I.O., Kochetov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/88

The aspects of analytical determination of disinfectants derivatives of the phenol series аrе considered. The possibility of codetermination of five derivatives of this series in different disinfectants using the RP-HPLC method in the isocratic mode (UV detection) is shown. Alternatively, the possibilities of the determination with the use of spectrophotometry and GC methods are considered. This study and previous ones showed that the extraction of phenol derivatives by organic solvents from а wide range of disinfectants is feasible only in some cases, preferably with the use of hexane as an extractant. Further spectrophotometry of hexane extracts does not always enable to correctly compensate for the effect of background impurities and requires an additional separation of the components. The literature data and experimental results suggest that it is more efficient to analyze the whole series of disinfectants in isopropanol (sometimes in water) by chromatographic methods, preferably by HPLC. Sample preparation reduces to the solubilization of batches of ready-made disinfectants in isopropanol/water. It is optimal to carry out the chromatographic study using elution with acetonitrile-based systems (for example, СН3СN:Н2O, 60:40) providing the correct determination (λ = 280 nт) of phenol derivatives. The completeness of extraction (if the extraction method is used), as well as the metrology aspects of all the analytical determination is set directly in а laboratory during the realization of procedures of introduction/validation according to the internal documents of the system quality management for the relevant structural unit.

Рассмотрены аспекты аналитического определения дезинфектантов производных ряда фенола. Показана возможность совместного определения пяти производных данного ряда в различных дезинфицирующих средствах с использованием ОФ ВЭЖХ в изократическом режиме (УФ-детектирование). Альтернативно рассмотрены возможности определения с использованием методов спектрофотометрии и ГЖХ. Настоящее и предшествующие исследования показали, что экстракционное извлечение производных группы фенола органическими растворителями из широкого спектра дезинфицирующих средств доступно только в некоторых случаях, преимущественно при использованием гексана в качестве экстрагента. В дальнейшем спектрофотометрирование гексановых экстрактов не всегда позволяет корректно скомпенсировать влияние фоновых примесей и требует дополнительного разделения компонентов. Исходя из литературных данных и результатов экспериментов, стоит отметить, что производительнее осуществлять анализ всей линейки дезинфекционных препаратов в изопропаноле (иногда в воде) хроматографическими методами, отдавая предпочтение ВЭЖХ. При этом пробоподготовка сводится к солюбилизации навесок готовых средств в изопропаноле/воде. Хроматографическое исследование оптимально проводить с применением в качестве элюента систем на основе ацетонитрила, обеспечивающих корректное определение (λ = 280 нм) производных фенола.

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The authors declare that there are no conflicts of interest present.