chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).chemicallytech-449Research ArticleCHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙBacterial endotoxins properties and methods of removing them from biopharmaceutical drugsСвойства бактериальных эндотоксинов и методы их удаления из биофармацевтических препаратовЖуравкоА. С.ZhuravkoA. S.

кафедра Биотехнологии и бионанотехнологии, аспирант

nastasya_Zh@mail.ruШвецВ. И.ShvetsV. I.

кафедра Биотехнологии и бионанотехнологии, заведующий кафедрой, академик РАН

noemail@neicon.ruМИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86РоссияM.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571Russian Federation201428082014942733Copyright © Zhuravko A.S., Shvets V.I., 20142014Журавко А.С., Швец В.И.Zhuravko A.S., Shvets V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/449

The production of biopharmaceutical proteins by means of Escherichia coli cultivation leads to contamination with bacterial endotoxins which are very toxic and pyrogenic impurities. The final product purification from these impurities is one of the most important tasks in the production of biopharmaceutical drugs. However, isolation of proteins from cellular biomass results in the formation of strong endotoxin-protein complexes that considerably complicate the task of obtaining pharmaceutical safely drugs. The goal of the present mini-review consisted in considering and discussing effective methods of removing bacterial endotoxins from protein solutions on the basis of their chemical and biological properties.

В мини-обзоре рассматриваются химические и биологические свойства бактериальных эндо- токсинов и современные наиболее удобные и эффективные методы удаления их из био-фармацевтических препаратов.

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The authors declare that there are no conflicts of interest present.