chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).chemicallytech-431Research ArticleCHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress8-оксо-2’-дезоксигуанозин - биомаркер окислительного стрессаНевредимоваТ. С.NevredimovaT. S.

кафедра Биотехнологии и бионанотехнологии, аспирант

NevredimovaTS@gmail.comМармийН. В.MarmiyN. V.

кафедра Биоорганической химии, Биологический факультет, аспирант

noemail@neicon.ruЕсиповД. С.EsipovD. S.

кафедра Биоорганической химии, Биологический факультет, доцент

noemail@neicon.ruЕсиповаО. В.EsipovaO. V.

кафедра Биотехнологии и бионанотехнологии, доцент

noemail@neicon.ruШвецВ. И.ShvetsV. I.

кафедра Биотехнологии и бионанотехнологии, заведующий кафедрой, академик РАН

noemail@neicon.ruМИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86Russian FederationМосковский государственный университет им. М.В. Ломоносова, Москва, 119991Russian FederationМИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86РоссияM.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571Russian Federation20142810201495310Copyright © Nevredimova T.S., Marmiy N.V., Esipov D.S., Esipova O.V., Shvets V.I., 20142014Невредимова Т.С., Мармий Н.В., Есипов Д.С., Есипова О.В., Швец В.И.Nevredimova T.S., Marmiy N.V., Esipov D.S., Esipova O.V., Shvets V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/431

Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in a cause of many diseases, including cancer, neurodegenerative diseases, atherosclerosis and aging. So in nuclear and mitochondrial DNA, guanine hydroxylation to 8-position gives 8­hydroxy­2'­deoxyguanosine (8­OH­dG) and 8­oxo­7,8­dihydro­2'­deoxyguanosine (8­oxo­dG). These substances are one of the predominant products of free radical­induced oxidative damages. They are usually been applied as biomarkers of oxidative stress and carcinogenesis. The direct oxidation of guanine or incorrect inclusion of 8-oxo-dGTP from the nucleotide pool by polymerases, lead to a lack of specificity of the base pairing in DNA, favoring mutagenesis. Firstly 8-oxo-dG has been described by H. Kasai and S. Nishimura in 1983. Since then, this damage has been widely measured in various tissues and body fluids as blood, urine, brain, liver, and others. Today 8-oxo-dG is already used not only as a marker of oxidative stress, but also as a tool for prognosis of diseases and results of applied therapy. Now many efforts are focused on developing the procedure of measurement of 8-oxo-dG content in tissues and body fluids. In this paper we also discuss the role of the 8-oxo-dG as a biomarker of oxidative stress and a predictor of diseases and results of the applied therapy.

8-Оксо-2’-дезоксигуанозин (8-oxo-dG) является преобладающей формой свободнорадикального повреждения ДНК. C момента его обнаружения в 1983 году, это соединение определяют в различных тканях и жидкостях организма: в крови, моче, мозге, печени и др. В данном обзоре рассматривается роль 8-oxo-dG в качестве биомаркера окислительного стресса, предиктора течения заболевания и успеха применяемой терапии у больных, а также методы, с помощью которых он сегодня детектируется в биологических образцах.

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The authors declare that there are no conflicts of interest present.