chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).chemicallytech-242Research ArticleCHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙNeoglycoconjugates for the delivery of nucleic acids into eucaryotic cellsНеогликоконъюгаты для доставки нуклеиновых кислот в эукариотические клеткиМасловМ. А.MaslovM. A.

Кафедра химии и технологии биологически активных соединений им. Н.А. Преображенского, профессор

mamaslov@mail.ruМорозоваН. Г.MorozovaN. G.

Кафедра химии и технологии биологически активных соединений им. Н.А. Преображенского, доцент

noemail@neicon.ruМИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86РоссияM.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571Russian Federation201528082015104521Copyright © Maslov M.A., Morozova N.G., 20152015Маслов М.А., Морозова Н.Г.Maslov M.A., Morozova N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/242

А development of stable and safety non-viral transport systems for delivery of therapeutic nucleic acids (NA) into the target cells is one of the problem of gene therapy. Cationic liposomes are promising delivery systems capable to transfer various kind of NA. However, the wide application of cationic liposomes for gene therapy purposes is limited by their low efficiency and unspecific NA delivery into cells. These drawbacks are related to the presence of different biological barriers for lipoplexes: the instability in biological fluids, the interaction with blood serum proteins, plasmatic and nucleic membranes and endosomal degradation. Modular gene delivery systems introduced ten years ago consist of different lipophilic modules that mediate environmental and cellular receptors interactions as well as intracellular trafficking. Modular systems containing synthetic neoglycolipids are widely used for development of targeted gene delivery based on specific carbohydrate-lectin interactions (glycotargeting). This review combines examples of neoglycolipids used as active components of cationic liposomes. Targeted delivery of plasmid DNA, mRNA, oligonucleotides and small interfering RNA into hepatocytes, Kupffer cells and dendritic cells are discussed.

В данном обзоре рассмотрены вопросы, связанные с конструированием адресных липидных систем доставки нуклеиновых кислот. Особое внимание уделено липофильным неогликоконъюгатам, которые используются в качестве адресного модуля системы доставки и способствуют направленному переносу ДНК, РНК и олигонуклеотидов в клетки печени или дендритные клетки.

липосомынеогликоконъюгатынуклеиновые кислотынаправленная доставкагенная терапия.liposomesneoglycoconjugatesnucleic acidstargeted deliverygene therapy.ReferencesTempleton N.S. Optimization of nonviral gene therapeutics / In: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 3 ed. / Ed. N.S. Templeton. Воса Raton: CRC Press, 2009. 1120 p.Templeton N.S. Optimization of nonviral gene therapeutics / In: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 3 ed. / Ed. N.S. Templeton. Воса Raton: CRC Press, 2009. 1120 p.Blau H.M., Springer M.L. // N. Engl. J. Med. 1995. V. 333. P. 1204-1207.Blau H.M., Springer M.L. // N. Engl. J. Med. 1995. V. 333. P. 1204-1207.Verma I.M., Weitzman M.D. // Ann. Rev. Biochem. 2005. V. 74. P. 711-738.Verma I.M., Weitzman M.D. // Ann. Rev. Biochem. 2005. V. 74. P. 711-738.Huang L. Non-viral vectors for gene therapy. 2nd ed. Part 1. / Huang L., Hung M.C., Wagner E. / Advances in Genetics. Amsterdam: Elsevier Academic Press, 2005. 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The authors declare that there are no conflicts of interest present.