chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).10.32362/2410-6593-2024-19-4-372-383CNMDMLchemicallytech-2128Research ArticleANALYTICAL METHODS IN CHEMISTRY AND CHEMICAL TECHNOLOGYАНАЛИТИЧЕСКИЕ МЕТОДЫ В ХИМИИ И ХИМИЧЕСКОЙ ТЕХНОЛОГИИDevelopment of a new inversion-voltammetric technique in determining inorganic iodine in Laminariae thalli L. for the quality control of raw materials in factory laboratoriesРазработка новой инверсионно-вольтамперометрической методики определения неорганического йода в слоевищах ламинарии (Laminariae thalli L.) для контроля качества сырья в условиях заводских лабораторийhttps://orcid.org/0009-0004-2755-2734НикулинА. В.NikulinA. V.

Никулин Александр Владимирович - д.фарм.н., доцент кафедры аналитической химии им. И.П. Алимарина, Институт тонких химических технологий им. М.В. Ломоносова, Scopus Author ID 57194137763.

119571, Москва, пр-т Вернадского, д. 86

Alexander V. Nikulin - Dr. Sci.(Pharm.) Associate Professor, I.P. Alimarin Department of Analytical Chemistry, M.V. Lomonosov Institute of Fine Chemical Technologies, Scopus Author ID 57194137763.

86, Vernadskogo pr., Moscow, 119571

alexander_sinus@mail.ruhttps://orcid.org/0000-0001-9861-7890МартыновЛ. Ю.MartynovL. Yu.

Мартынов Леонид Юрьевич - к.х.н., доцент кафедры аналитической химии им. И.П. Алимарина, Институт тонких химических технологий им. М.В. Ломоносова, Scopus Author ID 56084953700

119571, Москва, пр-т Вернадского, д. 86

Leonid Yu. Martynov - Cand. Sci.(Chem.), Associate Professor, I.P. Alimarin Department of Analytical Chemistry, M.V. Lomonosov Institute of Fine Chemical Technologies, Scopus Author ID 56084953700.

86, Vernadskogo pr., Moscow, 119571

martynov_leonid@mail.ruhttps://orcid.org/0009-0002-7095-1453ГабаеваР. С.GabaevaR. S.

Габаева Рамнат Султановна - магистрант, Институт тонких химических технологий им. М.В. Ломоносова.

119571, Москва, пр-т Вернадского, д. 86

Ramnat S. Gabaeva - Master Student, M.V. Lomonosov Institute of Fine Chemical Technologies.

86, Vernadskogo pr., Moscow, 119571

radima.gabaeva@yandex.ruhttps://orcid.org/0000-0001-8578-1683ЛазовМ. А.LazovM. A.

Лазов Михаил Александрович - к.х.н., доцент кафедры аналитической химии им. И.П. Алимарина, Институт тонких химических технологий им. М.В. Ломоносова, Scopus Author ID 56466030700.

119571, Москва, пр-т Вернадского, д. 86

Mikhail A. Lazov - Cand. Sci. (Chem.), Assistant Professor, I.P. Alimarin Department of Analytical Chemistry, M.V. Lomonosov Institute of Fine Chemical Technologies, Scopus Author ID 56466030700.

86, Vernadskogo pr., Moscow, 119571

lazov@mirea.ruМИРЭА — Российский технологический университет (Институт тонких химических технологий им. М.В. Ломоносова)РоссияMIREA — Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)Russian Federation202412092024194372383Copyright © Nikulin A.V., Martynov L.Y., Gabaeva R.S., Lazov M.A., 20242024Никулин А.В., Мартынов Л.Ю., Габаева Р.С., Лазов М.А.Nikulin A.V., Martynov L.Y., Gabaeva R.S., Lazov M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/2128Objectives

Objectives. To develop and validate a methodology for determining inorganic iodine in Laminariae thalli L., corresponding to the norms of the State Pharmacopoeia of the Russian Federation, 15th edition (SPh 15). The methodology needs to be valid and suitable for the quality control of pharmaceutical raw materials in factory laboratories.

Methods

Methods. Cathode inversion voltammetry was used as an instrumental method for determining inorganic iodine using a graphite electrode capable of sorbing electroactive ion associates of surfactant–iodine.

Results

Results. When compared with the titrimetric technique recommended by SPh 15, the proposed technique is more selective, sensitive and less time-consuming. The efficiency and metrological characteristics of the technique were confirmed by validation in accordance with the requirements of SPh 15.

Conclusion

Conclusion. The paper presents a new method for determining the gross content of inorganic iodine in Laminariae thalli L. This technique can be used not only in scientific research, but also in the routine quality control of medicinal plant raw materials in control and analytical laboratories engaged in pharmaceutical quality control.

Цели

Цели. Разработка и валидация методики определения неорганического йода в талломе ламинарии (Laminariae thalli L.), соответствующей нормам Государственной Фармакопеи Российской Федерации XV издания (ГФ РФ XV). Методика должна быть валидной и пригодной для контроля качества фармацевтического сырья в условиях заводских лабораторий.

Методы

Методы. В качестве инструментального метода определения неорганического йода была применена катодная инверсионная вольтамперометрия с использованием графитового электрода, способного сорбировать электроактивные ионные ассоциаты поверхностно-активного вещества (ПАВ)–йода.

Результаты

Результаты. По сравнению с титриметрической методикой, рекомендуемой ГФ РФ XV, предлагаемая методика более селективна, чувствительна и менее трудоемка. Работоспособность и метрологические характеристики методики были подтверждены валидацией согласно требованиям ГФ РФ XV.

Выводы

Выводы. В работе представлена новая методика определения валового содержания неорганического йода в слоевищах ламинарии (Laminariae thalli L.). Данная методика может быть использована не только в научных исследованиях, но и в рутинном контроле качества лекарственного растительного сырья в контрольно-аналитических лабораториях, занимающихся фармацевтическим контролем качества.

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The authors declare that there are no conflicts of interest present.