chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).10.32362/2410-6593-2023-18-1-38-47chemicallytech-1931Research ArticleCHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙScreening of medicinal plant extracts in Vietnam and investigation of their combination for preventing and treating goutСкрининг экстрактов лекарственных растений во Вьетнаме и исследование их комбинации для профилактики и лечения подагрыhttps://orcid.org/0000-0001-7919-4028АньК. ХаAnhC. Ha

Ань К. Ха, PhD, к.ф.н., Химико-технологический факультет

268 Ли Тхыонг Кьет ул., Район 10, г. Хошимин

Линь Чунг Уорд, Район Тхёк, г. Хошимин

Scopus Author ID 56485522100

Anh C. Ha, PhD, Doctor of Medicinal Chemistry, Faculty of Chemical Engineering

268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City

Linh Trung Ward, Thu Duc District, Ho Chi Minh City

Scopus Author ID 56485522100

hcanh@hcmut.edu.vnhttps://orcid.org/0000-0002-7956-1067ТанМ. ЛеTanM. Le

Тан М. Ле, аспирант, Химико-технологический факультет

268 Ли Тхыонг Кьет ул., Район 10, г. Хошимин

Линь Чунг Уорд, Район Тхёк, г. Хошимин

Scopus Author ID 57220162555, ResearcherID GWC-6849-2022

Tan M. Le, Postgraduate Student, Faculty of Chemical Engineering

268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City

Linh Trung Ward, Thu Duc District, Ho Chi Minh City

Scopus Author ID 57220162555, ResearcherID GWC-6849-2022

 

minhtan.le997@gmail.comТехнологический университет Хошимина; Вьетнамский национальный университет ХошиминаВьетнамHo Chi Minh City University of Technology; Vietnam National University Ho Chi Minh CityViet Nam2023200320231813847Copyright © Anh C.H., Tan M.L., 20232023Ань К.Х., Тан М.Л.Anh C.H., Tan M.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/1931

Objectives. The study aimed to examine the potential use of ethanol extracts of four medicinal plants to prevent and treat gout disease.Methods. An investigation of some typical compound contents such as polyphenols, flavonoids, and tannins in terms of two bioactive abilities, including anti-xanthine oxidase and antioxidant was carried out in Eclipta prostrata L., Artemisia vulgaris L., Apium graveolens L., and Piper betle L samples. Subsequently, the weight ratios of Piper betle L. and Artemisia vulgaris L. were investigated to reduce the total tannin content and get the most suitable anti-xanthine oxidase activity.Results. As well as having the highest target compound contents, Piper betle L. demonstrated the best anti-xanthine oxidase and antioxidant abilities even while its IC50 values were lower than positive control; however, its high total tannin content can cause some side effects. A mixture with a weight ratio of 1:1 of Piper betle L. and Artemisia vulgaris L. had a total tannin content half that of Piper betle L. as well as demonstrating potential anti-xanthine oxidase and antioxidant activities when IC50 was about 3.94 and 20.85 µg/mL, respectively.Conclusions. Out of the four selected plants, Piper betle L. demonstrated the best potential material for preventing and treating gout disease. However, due to the high tannin content in it, a mix of Piper betle L. and Artemisia vulgaris L. at a weight ratio of 1:1 gave optimal results for application in treatment.

Цели. Изучить потенциальное использование этанольных экстрактов четырех лекарственных растений для профилактики и лечения подагры.Методы. Образцы эклипты простёртой (Eclipta prostrata L.), полыни обыкновенной (Artemisia vulgaris L.), сельдерея пахучего (Apium graveolens L.) и перца бетель (Piper betle L. ) исследовались с точки зрения содержания в них полифенолов, флавоноидов и дубильных веществ, а также наличия биологически активных свойств, включая антиксантиноксидазную и антиоксидантную активность. Далее были найдены весовые соотношения Piper betle L. и Artemisia vulgaris L., позволяющие снизить общее содержание танина и получить наиболее подходящую антиксантиноксидазную активность.Результаты. Помимо самого высокого содержания целевого соединения, Piper betle L. продемонстрировал наилучшие антиксантиноксидазные и антиоксидантные свойства, даже несмотря на то, что его значения IC50 были ниже положительного контроля. Однако высокое содержание общего танина в нем может вызывать некоторые побочные эффекты. Смесь Piper betle L. и Artemisia vulgaris L. с массовым соотношением 1:1 имела общее содержание танина вдвое меньше, чем Piper betle L., а также демонстрировала потенциальную антиксантиноксидазную и антиоксидантную активность, при этом IC50 составлял около 3.94 и 20.85 мкг/мл соответственно.Выводы. Из четырех отобранных растений Piper betle L. является наилучшим потенциальным материалом для профилактики и лечения подагры. Однако из-за высокого содержания в нем танина смесь Piper betle L. и Artemisia vulgaris L. в соотношении по массе 1:1 дала оптимальные результаты для применения в лечении.

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The authors declare that there are no conflicts of interest present.