chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).10.32362/2410-6593-2019-14-1-59-65chemicallytech-188Research ArticleCHEMISTRY AND TECHNOLOGY OF INORGANIC MATERIALSХИМИЯ И ТЕХНОЛОГИЯ НЕОРГАНИЧЕСКИХ МАТЕРИАЛОВTHE METHOD FOR OBTAINING A DERIVATIVE CLOSO-DECABORATE ANION WITH PENDANTE DTPA-GROUPМЕТОД ПОЛУЧЕНИЯ ПРОИЗВОДНОГО КЛОЗО-ДЕКАБОРАТНОГО АНИОНА С ПЕНДАНТНОЙ DTPA-ГРУППОЙМатвеевЕ. Ю.MatveevE. Yu.

научный сотрудник лаборатории химии легких элементов и кластеров

119991, Россия, Москва, Ленинский проспект, д. 31

Ph.D. (Chemistry), Associate Professor of the A.N. Reformatskiy Chair of Inorganic Chemistry,

86, Vernadskogo pr., Moscow 119571, Russia

Researcher at the Laboratory of Chemistry of Light Elements and Clusters,

31, Leninsky pr., Moscow, 119991, Russia

eyumatveev@mitht.ruАкимовС. С.AkimovS. S.

кандидат химических наук, менеджер

115230, Россия, Москва, Каширское шоссе, д. 9, корп. 3

Ph.D. (Chemistry), Manager

9 (bld. 3), Kashirskoe shosse, Moscow, 115230, Russia

noemail@neicon.ruКубасовА. С.KubasovA. S.

кандидат химических наук, научный сотрудник лаборатории химии легких элементов и кластеров

119991, Россия, Москва, Ленинский проспект, д. 31

Ph.D. (Chemistry), Researcher at the Laboratory of Chemistry of Light Elements and Clusters,

31, Leninsky pr., Moscow, 119991, Russia

noemail@neicon.ruРетивовВ. М.RetivovV. M.

кандидат химических наук, заведующий аналитическим испытательным центром

107076, Россия, г. Москва, Богородский вал, д. 3

Ph.D. (Chemistry), Head of the Analytical Testing Center,

3, Bogorodsky Val, Moscow, 107076, Russia

noemail@neicon.ruЖижинК. Ю.ZhizhinK. Yu.

 

 

D.Sc. (Chemistry), Corresponding Member of RAS, Professor of the A.N. Reformatskiy Chair of Inorganic Chemistry,

86, Vernadskogo Pr., Moscow 119571, Russia

Deputy Director for Research

31, Leninsky pr., Moscow, 119991, Russia

noemail@neicon.ruКузнецовН. Т.KuznetsovN. T.

доктор химических наук, академик, заведующий лабораторией химии легких элементов и кластеров

119991, Россия, Москва, Ленинский проспект, д. 31

D.Sc. (Chemistry), Academician of RAS, Head of the Laboratory of Chemistry of Light Elements and Clusters

31, Leninsky pr., Moscow, 119991, Russia

noemail@neicon.ruКандидат химических наук, доцент кафедры неорганической химии им. А.Н. Реформатского, МИРЭА - Российский технологический университет (Институт тонких химических технологий имени М.В. Ломоносова), 119571, Россия, Москва, пр. Вернадского, д. 86; Институт общей и неорганической химии им. Н.С. Курнакова Российской академии наукРоссияMIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies); Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of SciencesRussian FederationООО “Химмед”РоссияKhimmed Ltd.Russian FederationИнститут общей и неорганической химии им. Н.С. Курнакова Российской академии наукРоссияKurnakov Institute of General and Inorganic Chemistry, Russian Academy of SciencesRussian FederationФГУП “ИРЕА”РоссияFederal State Unitary Enterprise “Research Institute of Chemical Reagents and High-Purity Chemical Substances”Russian FederationДоктор химических наук, член-корреспондент РАН, профессор кафедры неорганической химии им. А.Н. Реформатского, МИРЭА - Российский технологический университет (Институт тонких химических технологий имени М.В. Ломоносова), 119571, Россия, Москва, пр. Вернадского, д. 86. Заместитель директора по научной работе, Институт общей и неорганической химии им. Н.С. Курнакова Российской академии наук, 119991, Россия, Москва, Ленинский проспект, д. 31.РоссияMIREA - Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies); Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of SciencesRussian Federation2019280220191415965Copyright © Matveev E.Y., Akimov S.S., Kubasov A.S., Retivov V.M., Zhizhin K.Y., Kuznetsov N.T., 20192019Матвеев Е.Ю., Акимов С.С., Кубасов А.С., Ретивов В.М., Жижин К.Ю., Кузнецов Н.Т.Matveev E.Y., Akimov S.S., Kubasov A.S., Retivov V.M., Zhizhin K.Y., Kuznetsov N.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/188

This paper describes the method for obtaining a new derivative of the closo-decaborate anion with diethylenetriaminepentaacetic acid (DTPA) as a pendant group attached to the boron cluster through an alkoxyl spacer chain. This derivative is formed by the interaction of 1,4-dioxane derivative of the anion [B10H10]2- with DTPA potassium salt in an aqueous medium. As a result of the reaction, an exo-polyhedral cyclic substituent is opened, and then the addition of a polyfunctional group through an oxygen atom occurs. The synthesized compound is in fact an effective polydentate ligand capable of coordinating to the complexing agent both due to the donor atoms of the attached DTPA fragment and through the formation of three-center two-electron bonds. The obtained compound interacts with gadolinium(III) carbonate forming a complex of the composition [Gd2B10H9O2C4H8(dtpa)]·3H2O. The synthesized substances were studied by IR spectroscopy, polynuclear (11B, 13C and 1H) NMR spectroscopy, ESI mass spectrometry, elemental and thermographic analysis. closo-Decaborate with the pendant DTPA group is of interest in 10B neutron capture therapy of malignant tumors due to the high content of boron atoms and a convenient way of their transport to the affected cells. The obtained boron-containing derivatives of gadolinium(III) can act as drugs of combined action, because they can perform, in addition to the above described therapeutic function, the diagnostic function due to the presence of gadolinium atoms int hem.

В статье описан метод получения нового производного клозо-декаборатного аниона с диэтилентриаминпентауксусной кислотой (DTPA) в качестве пендантной группы, присоединенной к борному кластеру через алкоксильную спейсерную цепочку. Оно образуется при взаимодействии 1,4-диоксанового производного аниона [B10H10]2- с калийной солью DTPA в водной среде. В результате реакции происходит раскрытие экзо-полиэдрического циклического заместителя с последующим присоединением полифункциональной группы через атом кислорода. Синтезированное соединение по сути является эффективным полидентатным лигандом, способным координироваться к комплексообразователю как за счет донорных атомов присоединенного фрагмента DTPA, так и посредством образования трехцентровых двухэлектронных связей. Полученное соединение вступает во взаимодействие с карбонатом гадолиния(III), образуя комплекс состава [Gd2(B10H9O2C4H8(dtpa))]‧3H2O. Синтезированные вещества исследованы методами ИК-спектроскопии, полиядерной (11B, 13C и 1H) ЯМР-спектроскопии, ESI-масс-спектрометрии, элементного и термографического анализа. клозо-Декабораты с пендантной DTPA-группой представляют интерес для 10B-нейтронозахватной терапии злокачественных опухолей благодаря высокому содержанию атомов бора и удобному способу их транспорта к пораженным клеткам. Полученные борсодержащие производные гадолиния(III) могут выступать в качестве препаратов сочетанного действия, так как помимо вышеописанной терапевтической функции способны выполнять и диагностическую - за счет наличия в них атомов гадолиния.

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The authors declare that there are no conflicts of interest present.