chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).10.32362/2410-6593-2021-16-6-465-475chemicallytech-1769Research ArticleCHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙMicrofluidic method as a promising technique for synthesizing antimicrobial compoundsМикрофлюидный метод как перспективная технология для синтеза антимикробных соединенийhttps://orcid.org/0000-0001-7919-4028ХаА. К.HaA. С.

Ань К. Ха – PhD, кандидат химических наук, Химико-технологический факультет, Технологический университет Хошимина; Вьетнамский НУ Хошимина, Scopus Author ID 56485522100

268 Ли Тхыонг Кьет ул., г. Хошимин; Район Тхёк, г. Хошимин

Anh C. Ha - PhD, Dr. Sci. in Chemical Engineering, Faculty of Chemical Engineering, Scopus Author ID 56485522100

268 Ly Thuong Kiet Street, District 10, Ho Chi Minh CityLinh Trung Ward, Thu Duc District, Ho Chi Minh City

hcanh@hcmut.edu.vnТехнологический университет Хошимина; Вьетнамский национальный университетВьетнамHo Chi Minh City University of Technology (HCMUT); Vietnam National University Ho Chi Minh City (VNU-HCM)Viet Nam202126012022166465475Copyright © Ha A.С., 20222022Ха А.К.Ha A.С.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/1769Objectives

Objectives. The study aimed to analyze the current antiseptics and disinfectants, explore the possibility of synthesizing various antiseptics including oligohexamethylene guanidine hydrochloride (OHMG-HC) using microfluidic technology, and investigate the main synthesis parameters affecting the properties of the resulting product.

Methods

Methods. This article presented a review of literature sources associated with investigations of antimicrobial resistance, the uses of agents based on polyhexamethylene guanidine hydrochloride, oligohexamethylene guanidine hydrochloride, and other salts, obained using modern synthesis technologies with microreactors.

Results

Results. The relevance of developing production technologies for the “OHMG-HC branched” substance was determined. The microfluidic method for the synthesis of polymers, and its application prospects for obtaining the target substance were compared with the existing methods. Advantages of the microfluidic method were indicated.

Conclusions

Conclusions. Microreactor technologies allow for more accurate control of the conditions of the polycondensation reaction of the starting monomers and increase the yield and selectivity of the oligomers obtained, leading to an increase in the product purity and process efficiency, in contrast with other known methods. The use of microreactor technologies for the synthesis of branched oligohexamethylene guanidine hydrochloride products is a promising strategy.

Цели

Цели. Цель исследования – проанализаровать применяющиеся антисептики и дезинфектанты, рассмотреть возможность синтеза различных антисептиков и отдельно синтеза олигогексаметиленгуанидина гидрохлорида (ОГМГ-ГХ) с применением микрофлюидной технологии, а также изучить основные параметры синтеза, влияющие на характеристики получаемого продукта.

Методы

Методы. Представлен обзор литературных источников, связанных с иследованиями антимикробной резистентности, применением средств на основе полигексаметиленгуанидина гидрохлорида, олигогексаметиленгуанидина гидрохлорида, а также других солей, полученных современными технологиями синтеза с использованием микрореакторов.

Результаты

Результаты. Определена актуальность разработки технологии получения субстанции «ОГМГ–ГХ разветвленный». Рассмотрены существующие способы получения субстанции и их недостатки. Также рассмотрен микрофлюидный способ синтеза полимеров, его достоинства и перспективы его использования для получения целевой субстанции.

Выводы

Выводы. Микрореакторные технологии позволяют более точно контролировать условия реакции поликонденсации исходных мономеров и повышать выход и селективность полученных олигомеров, что приводит к повышению чистоты продукта и эффективности процесса, в отличие от других известных способов. Использование микрореакторных технологий для синтеза разветвленных продуктов гидрохлорида олигогексаметиленгуанидина является перспективной стратегией.

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The authors declare that there are no conflicts of interest present.