chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).10.32362/2410-6593-2019-14-4-7-23chemicallytech-1280Research ArticleREVIEW ARTICLESОБЗОРНЫЕ СТАТЬИRibavirin and its analogs: Сan you teach an old dog new tricks?Рибавирин и его аналоги: можно ли старую собаку научить новым фокусам?https://orcid.org/0000-0001-9735-9690ЧудиновМ. В.ChudinovM. V.

кандидат химических наук, доцент кафедры биотехнологии и промышленной фармации 

ResearcherID L-5728- 2016

119571, Россия, Москва, пр-т Вернадского, д. 86

Cand. of Sci. (Chemistry), Associate Professor of the Chair of Biotechnology and Industrial Pharmacy

ResearcherID L-5728-2016

86, Vernadskogo pr., Moscow 119571, Russia

chudinov@mirea.ruМИРЭА – Российский технологический университет (Институт тонких химических технологий имени М.В. Ломоносова)РоссияMIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)Russian Federation201931082019144723Copyright © Chudinov M.V., 20192019Чудинов М.В.Chudinov M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/1280

The review article focuses on the current state of synthetic and biological studies of ribavirin analogs. Ribavirin is a broad-spectrum nucleoside antiviral drug with a 50-year long history of research and application, but its mechanism of action still remains unclear. This article examines contemporary views on the antiviral and antitumor effects of ribavirin and its analogs and describes the contradictions and gaps that exist in our knowledge. In recent years, new nucleoside analogs of ribavirin have been synthesized. These ribavirin derivatives modified at the heterocyclic base, have the potential to become the antiviral and antitumor agents of the new generation. Thus, this paper presents a systematic review of antiviral activities, antitumor activities and structure–activity relationship (SAR) correlations of 39 ribavirin analogs created in the past 15 years. Biological targets and possible mechanisms of action of these new compounds are also discussed, as well as the prospects and possible directions for further research.

Обзор посвящен современному состоянию синтетических и биологических исследований аналогов рибавирина. Рибавирин – нуклеозидный противовирусный препарат широкого спектра действия с 50-ти-летней историей исследований и применения, но механизмы его действия до сих пор остаются неясными. В обзоре кратко изложены современные взгляды на биологические механизмы противовирусного и противоопухолевого действия рибавирина и его аналогов, существующие в этих взглядах противоречия и пробелы. В течение последних лет получены новые нуклеозидные аналоги – производные рибавирина по гетероциклическому основанию, потенциально представляющие собой противовирусные и противоопухолевые средства нового поколения. В статье дан систематический обзор исследований противовирусной и противоопухолевой активности и корреляций «структура – активность», в общей сложности, для 39 аналогов рибавирина, представленных за последние 15 лет, обсуждаются биологические мишени и возможные механизмы действия этих новых соединений, а также перспективы и направление дальнейших исследований.

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The authors declare that there are no conflicts of interest present.