chemicallytechFine Chemical TechnologiesТонкие химические технологии2410-65932686-7575MIREA – Russian Technological University (RTU MIREA).chemicallytech-1113Research ArticleCHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCESХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙThe preparation of 1-(β-naphthyl)-3-ferrocenylpyrazole-4-carbaldehyde and syntheses on the base of itПолучение 1-(-β-нафтил)-3-ферроценилпиразол-4- карбальдегида и синтезы на его основеОсиповаЕ. Ю.OsipovaE. Yu.

кафедра Химии и технологии биологически активных соединений им. Н.А. Преображенского, студент

noemail@neicon.ruСименелА. А.SimenelA. A.

научный сотрудник

alexsim@ineos.ac.ruРодионовА. Н.RodionovA. N.

аспирант

noemail@neicon.ruКачалаВ. В.KachalaV. V.

научный сотрудник

noemail@neicon.ruЖеребкерК. Я.ZherebkerK. Ya.

кафедра Химии и технологии биологически активных соединений им. Н.А. Преображенского, старший лаборант

noemail@neicon.ruМИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86Russian FederationИнститут элементоорганических соединений им. А.Н. Несмеянова РАНRussian FederationИнститут органической химии им. Н.Д. Зелинского РАНRussian Federation20092804200942100105Copyright © Osipova E.Y., Simenel A.A., Rodionov A.N., Kachala V.V., Zherebker K.Y., 20092009Осипова Е.Ю., Сименел А.А., Родионов А.Н., Качала В.В., Жеребкер К.Я.Osipova E.Y., Simenel A.A., Rodionov A.N., Kachala V.V., Zherebker K.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.finechem-mirea.ru/jour/article/view/1113ацетилферроценреагент Вильсмеерапиразолывосстановительное аминированиетриацетоксиборгидридAcetylferroceneVilsmeier-Haack reagentpyrazoleSreductive aminationtriacetoxiborhydrideReferencesKatritzky, A. R. Comprehensive heterocyclic chemistry / A. R. Katritzky. - Pergamon Press Ltd, 1984. - Vol. 5, part 4A. - 994 p.Katritzky, A. R. Comprehensive heterocyclic chemistry / A. R. Katritzky. - Pergamon Press Ltd, 1984. - Vol. 5, part 4A. - 994 p.Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives Y. S. Xie [et al.] // J. Organomet. Chem. - 2008. - Vol. 693. - P. 1367-1374 .Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives Y. S. Xie [et al.] // J. Organomet. Chem. - 2008. - Vol. 693. - P. 1367-1374 .Ferrocenylalkyl azoles: bioactivity, synthesis, structure / L. V. Snegur, Yu. S. Nekrasov, N. S. Sergeeva, Zh. V. Zhilina, V. V Gumenyuk, Z. A. Starikova, A. A. Simenel, N. B. Morozova, I. K. Sviridova, V. N. Babin // Appl. Organomet. Chem. - 2008. - Vol. 22. - P. 139-147.Ferrocenylalkyl azoles: bioactivity, synthesis, structure / L. V. Snegur, Yu. S. Nekrasov, N. S. Sergeeva, Zh. V. Zhilina, V. V Gumenyuk, Z. A. Starikova, A. A. Simenel, N. B. Morozova, I. K. Sviridova, V. N. Babin // Appl. Organomet. Chem. - 2008. - Vol. 22. - P. 139-147.Some new aspects of asymmetric catalysis with chiral ferrocenyl ligands / A. Togni, R. Dorta, C. Kollner, G. Pioda // Pure and Appl. Chem. - 1998. - Vol. 70, № 8. - P. 1477-1485.Some new aspects of asymmetric catalysis with chiral ferrocenyl ligands / A. Togni, R. Dorta, C. Kollner, G. Pioda // Pure and Appl. Chem. - 1998. - Vol. 70, № 8. - P. 1477-1485.4-Functionally substituted 3-heterylpyrazoles: XVIII. Intramolecular cyclization of N-[3-(2-chlorophenyl)-4-pyrazolyl]methylamine and its N-alkyl derivatives into 4,5-dihydro-2H-pyrazolo[4,3- c]quinolines M. K. Bratenko, O. I. Panimarchuk, V. A. Chornous, M. V. Vovk // Russ. J. Org. Chem. - 2007. - Vol. 43, № 48. - P. 1209-1213.4-Functionally substituted 3-heterylpyrazoles: XVIII. Intramolecular cyclization of N-[3-(2-chlorophenyl)-4-pyrazolyl]methylamine and its N-alkyl derivatives into 4,5-dihydro-2H-pyrazolo[4,3- c]quinolines M. K. Bratenko, O. I. Panimarchuk, V. A. Chornous, M. V. Vovk // Russ. J. Org. Chem. - 2007. - Vol. 43, № 48. - P. 1209-1213.Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures / A. F. Abdel-Magid, K. G. Carson, B. D. Harris, C. A. Maryanoff, R. D. Shah // J. Org. Chem. - 1996. - Vol. 61. - P. 3849-3862.Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures / A. F. Abdel-Magid, K. G. Carson, B. D. Harris, C. A. Maryanoff, R. D. Shah // J. Org. Chem. - 1996. - Vol. 61. - P. 3849-3862.Felleher, F. Spirobicyclic diamines. Part 3: Synthesis and metal complexation of proline-derived [4.4]-spirodiamines F. Felleher, S. Kelly, V. McKee // Tetrahedron. - 2007. - Vol. 63. - P. 9235- 9242.Felleher, F. Spirobicyclic diamines. Part 3: Synthesis and metal complexation of proline-derived [4.4]-spirodiamines F. Felleher, S. Kelly, V. McKee // Tetrahedron. - 2007. - Vol. 63. - P. 9235- 9242.Portoghese, P. S. Design of peptidomimetic and opioid receptor antagonists using the message-address concept / P. S. Portoghese, M. Sultana, A.E. Takemori // J. Med. Chem. - 1990. - Vol. 33, № 6. - P. 1714-1720.Portoghese, P. S. Design of peptidomimetic and opioid receptor antagonists using the message-address concept / P. S. Portoghese, M. Sultana, A.E. Takemori // J. Med. Chem. - 1990. - Vol. 33, № 6. - P. 1714-1720.

The authors declare that there are no conflicts of interest present.