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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">chemicallytech</journal-id><journal-title-group><journal-title xml:lang="en">Fine Chemical Technologies</journal-title><trans-title-group xml:lang="ru"><trans-title>Тонкие химические технологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-6593</issn><issn pub-type="epub">2686-7575</issn><publisher><publisher-name>MIREA – Russian Technological University (RTU MIREA).</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">chemicallytech-1108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CHEMISTRY AND TECHNOLOGY OF MEDICINAL COMPOUNDS AND BIOLOGICALLY ACTIVE SUBSTANCES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИМИЯ И ТЕХНОЛОГИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ И БИОЛОГИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ</subject></subj-group></article-categories><title-group><article-title>Study of polysialated recombinant human insulin</article-title><trans-title-group xml:lang="ru"><trans-title>Исследование полисиалированного генно-инженерного инсулина человека</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корчажникова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Korchagnikova</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра Аналитической химии, аспирант</p></bio><email xlink:type="simple">korchagnikova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назимов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazimov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глубоков</surname><given-names>Ю. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Glubokov</surname><given-names>Yu. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра Аналитической химии, доцент</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Безуглов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bezuglov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий лабораторией</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571</institution><country>Russian Federation</country></aff></aff-alternatives><aff xml:lang="ru" id="aff-2"><institution>Институт биоорганической химии &#13;
им. акад. М.М. Шемякина и Ю.А. Овчинникова РАН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2009</year></pub-date><volume>4</volume><issue>2</issue><fpage>77</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Korchagnikova M.N., Nazimov I.V., Glubokov Y.M., Bezuglov V.V., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Корчажникова М.Н., Назимов И.В., Глубоков Ю.М., Безуглов В.В.</copyright-holder><copyright-holder xml:lang="en">Korchagnikova M.N., Nazimov I.V., Glubokov Y.M., Bezuglov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.finechem-mirea.ru/jour/article/view/1108">https://www.finechem-mirea.ru/jour/article/view/1108</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>рекомбинантный инсулин человеческий</kwd><kwd>модифицированный инсулин</kwd><kwd>полисиаловая кислота</kwd></kwd-group><kwd-group xml:lang="en"><kwd>recombinant human insulin</kwd><kwd>modified  insulin</kwd><kwd>polysialate acid</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Byrne, B. Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells / B. Byrne, G. G. Donohoe, R. O'Kennedy // Drug Discovery Today. - 2007. - Vol. 12. - P. 319-326.</mixed-citation><mixed-citation xml:lang="en">Byrne, B. Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells / B. Byrne, G. G. Donohoe, R. O'Kennedy // Drug Discovery Today. - 2007. - Vol. 12. - P. 319-326.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Polysialic acids: potential in drug delivery / G. Gregoriadis [et al.] // FEBS Lett. - 1993. - Vol. 315. - P. 271-276.</mixed-citation><mixed-citation xml:lang="en">Polysialic acids: potential in drug delivery / G. Gregoriadis [et al.] // FEBS Lett. - 1993. - Vol. 315. - P. 271-276.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Valuev, L. New possibilities for biospecific chromatography / L. Valuev, N. A. Platé // Appl. Biochem. and Microbiol. - 2003. - Vol. 39, № 4. - P. 22-42.</mixed-citation><mixed-citation xml:lang="en">Valuev, L. New possibilities for biospecific chromatography / L. Valuev, N. A. Platé // Appl. Biochem. and Microbiol. - 2003. - Vol. 39, № 4. - P. 22-42.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Аналитическая биотехнология рекомбинантных пептидов и белков. Анализ чистот, состава и структуры инсулинов человека, свиньи и крупного рогатого скота / Н. В. Сергеев, И. В. Назимов, В. Г. Гавриков, А. И. Мирошников // Биоорган. химия. - 2000. - Т. 26, № 1. - С. 25-30.</mixed-citation><mixed-citation xml:lang="en">Аналитическая биотехнология рекомбинантных пептидов и белков. Анализ чистот, состава и структуры инсулинов человека, свиньи и крупного рогатого скота / Н. В. Сергеев, И. В. Назимов, В. Г. Гавриков, А. И. Мирошников // Биоорган. химия. - 2000. - Т. 26, № 1. - С. 25-30.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Grau, U. Fingerprint analysis of insulin and proinsulins / U. Grau // Diabetus. - 1985. - Vol. 33. - P. 1174-1180.</mixed-citation><mixed-citation xml:lang="en">Grau, U. Fingerprint analysis of insulin and proinsulins / U. Grau // Diabetus. - 1985. - Vol. 33. - P. 1174-1180.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Дарбре, А. Практическая химия белка / А. Дарбре. - М. : Мир, 1989. - 623 с.</mixed-citation><mixed-citation xml:lang="en">Дарбре, А. Практическая химия белка / А. Дарбре. - М. : Мир, 1989. - 623 с.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
